Delayed-onset parkinsonism after carbon monoxide poisoning: neuropsychological perspectives from a case report

This case report presents the clinical evolution of a patient who developed delayed-onset parkinsonism and cognitive deficits following carbon monoxide poisoning (COP). After a symptom-free interval of approximately one month, the patient exhibited progressive neurological and cognitive impairments that significantly interfered with daily and occupational functioning. A combined therapeutic approach was implemented, involving pharmacological treatment, cycles of hyperbaric oxygen therapy (HBOT) and a tailored neuropsychological rehabilitation program. Longitudinal assessments documented progressive improvements, particularly in sustained attention, memory, and executive functioning, although residual difficulties persisted. This case highlights the relevance of individualized neuropsychological interventions in conjunction with medical treatment in facilitating functional recovery in patients with delayed neurological sequelae after COP.