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Il trading online nell’economia delle piattaforme. Un caso di lavoro senza lavoratori?

Il saggio affronta la questione della qualificazione giuridica dei trader che operano su piattaforme digitali, un fenomeno in rapida crescita che l'ordinamento fatica a inquadrare nelle categorie esistenti. Muovendo da un'analisi socio-economica del trading online in Italia, il contributo si interroga sull’opportunità di introdurre obblighi contributivi in capo ai soggetti che svolgono tale attività in modo organizzato e professionale, pur escludendo che essi possano essere inquadrati quali ...

Dual targeting of EphAs and KDR axis hampers VEGF-induced angiogenesis and glioma stem cell replication

Glioblastoma multiforme (GBM) is an aggressive and highly vascularized brain tumor with a poor prognosis and limited therapeutic options. Resistance to current treatments is largely driven by glioma stem-like cells (GSCs), a subpopulation with high tumorigenic potential that plays a key role in tumor progression, recurrence, and angiogenesis. Eph receptor tyrosine kinases, including EphA and EphB, are broadly implicated in GBM biology. While both classes contribute to tumor development and pl...

Reprogramming the mitochondrial–circadian energy code with incretins

AbstractMitochondrial dysfunction, circadian disruption, and the accumulation of senescent cells converge to impair metabolic flexibility, a unifying phenotype of obesity and aging. We frame obesity as a nutrient-driven and aging as a time-driven expression of a disrupted mitochondrial–circadian energy code, with shared outputs: impaired substrate switching and flattened energy rhythms. This opinion argues that restoring code integrity, indexed clinically by gains in metabolic flexibility, sh...

A time bridge for obesity care: protein monitoring adds a timing layer to the EASO pathway while preserving the Lancet Commission definition

The European Association for the Study of Obesity (EASO) frames obesity care around staged, target-driven decisions. The Lancet Diabetes & Endocrinology Commission provides a disease definition-clinical obesity requires objective dysfunction- and distinguishes preventive strategies for preclinical obesity from therapeutic strategies for clinical obesity. Continuous protein monitoring (CPM) refers to wearable or minimally invasive sensors that repeatedly measure short panels of proteins in int...

Usmani–Riazuddin Syndrome: Functional Characterization of a Novel c.196G>A Variant in the AP1G1 Gene and Phenotypic Insights Using Zebrafish as a Vertebrate Model

Adaptor Protein-1 (AP-1) is a heterotetrameric essential for intracellular vesicular trafficking and polarized localization of somato-dendritic proteins in neurons. Variants in the AP1G1 gene, encoding the gamma-1 subunit of adaptor-related protein complex 1 (AP1γ1), have recently been associated with Usmani–Riazuddin syndrome (USRISD, MIM#619467), a very rare human genetic disorder characterized by intellectual disability (ID), speech and neurodevelopmental delays. Here we report a novel var...

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