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SIGNED-PERTURBED SUMS ESTIMATION OF ARX SYSTEMS: EXACT COVERAGE AND STRONG CONSISTENCY

Sign-perturbed sums (SPS) is an identification method that constructs confidence regions for the unknown parameters of a system. In this paper, we consider a new version of SPS for application to autoregressive exogenous systems and establish that the ensuing confidence regions include the true parameters with exact, user-chosen, probability under mild statistical assumptions. This property holds true for any finite number of observed input-output data. Furthermore, the confidence regions are...

Mechanistic investigation on compounds from Amorpha fruticosa L. targeting acetylcholinesterase

Acetylcholinesterase (AChE) is the enzyme targeted by drugs used for the symptomatic treatment of cognitive decline associated with Alzheimer’s disease. While in vitro data suggest the AChE inhibitory potential of A. fruticosa extracts and components such as rotenoids, in-depth mechanistic investigations are missing. A wide array of computational techniques, including ligand-based approaches, molecular docking, molecular dynamics, and machine learning-assisted toxicity prediction were enrolle...

Inhibition of ectonucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1) by compounds from fernandoa adenophylla (wall. ex G.Don) Steenis

Ectonucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1) is an enzyme that regulates several downstream pathways related to hydrolyses 2′,3′-cyclic GMP-AMP dinucleotide (2′,3′-cGAMP) signalling, and compounds targeting ENPP1 may find future applications in cancer and immunomodulation. In this work, 5 molecules were extracted from Fernandoa adenophylla (Wall. ex G.Don) Steenis and tested in vitro against the phosphodiesterase, highlighting methyl 1,2-dihydroxy-2-(3-methylbut-2-enyl)-3-oxoind...

Fentanyl–Antibody Interaction as a Novel Strategy against Opiates and Opioids Abuse

While naloxone remains the antidote for opioid overdoses, more efficient tools are required to effectively combat this growing crisis. Vaccines and antibodies targeting substances of abuse appear to be a novel and promising approach to tackling the fentanyl and opioid epidemic. After an initial in-depth rundown on the pharmacodynamics of the substances involved from a structural and mechanistic standpoint, and a brief overview of pharmacological approaches used in clinical settings for managi...

The New Guarantee System for Monitoring Healthcare Services Delivery in Italy: technical remarks and recommendations

Background: Over the past 15 years, Italy's National Health Service has been the object of increased governmental attention, due to the need to control public spending, reduce waste, and maintain acceptable levels of quality, accessibility and appropriateness of healthcare services. Methods: One of the key mechanisms to achieve this has been the implementation of performance assessment systems. Among these is the New Guarantee System, introduced in 2019, which utilizes 88 indicators across th...

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