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Evaluating the optimal timing and capacity of investments in flexible combined heat and power generation for energy-intensive industries

Substantial R&D efforts are currently directed towards the development of combined heat and power (CHP) systems that automatically and seamlessly connect to the power grid. In this paper we develop a real options model to assess the impact that the operational flexibility characterizing such systems will have on the optimal timing and capacity associated with investments in CHP plants. We take the viewpoint of a manufacturer operating in an energy-intensive industry who contemplates investing...

A case of discrepant laboratory results in samples obtained from a central venous catheter and peripheral veins: when solving a pre-analytical mystery could improve patient care

: It is now generally accepted that laboratory errors or inaccurate results are mainly due to deficiencies in the pre-analytical phase. In this report, we describe the case of a 64-year-old male affected by a relapsing follicular lymphoma, who has been treated with chemotherapy through a central venous catheter (CVC). Four different samples were collected alternatively through peripheral venipuncture and CVC sampling. Unexpectedly, the samples collected from the two different sources showed c...

Radicalizzazione dei convertiti e possibili strategie di reinserimento

The phenomenon of radicalization of converts to Islam concerns a small number of the total sub-jects who undertake the path towards the new religious faith but the available data seem to in-dicate an over-representation within the group of violent extremists, who have perpetrated terrorist attacks in Europe and in the world. Despite this findings, the available studies are still in their in-fancy, far from being able to clearly define the peculiar elements that characterize the radical-izatio...

Social attention and social-emotional modulation of attention in Angelman syndrome: an eye-tracking study

: Individuals with Angelman syndrome (AS) present with severe intellectual disability alongside a social phenotype characterised by social communication difficulties and an increased drive for social engagement. As the social phenotype in this condition is poorly understood, we examined patterns of social attention and social modulation of attention in AS. Twenty-four individuals with AS and twenty-one young children with similar mental age were shown videos featuring unfamiliar actors who pe...

Comprehensive transcriptomic analysis to identify biological and clinical differences in cholangiocarcinoma

Background: Cholangiocarcinoma (CC) is a rare and aggressive disease with limited therapeutic options and a poor prognosis. All available public records of cohorts reporting transcriptomic data on intrahepatic cholangiocarcinoma (ICC) and extrahepatic cholangiocarcinoma (ECC) were collected with the aim to provide a comprehensive gene expression-based classification with clinical relevance. Methods: A total of 543 patients with primary tumor tissues profiled by RNAseq and microarray platforms...

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