Abiraterone acetate (AbiAc) inhibits tumor growth when administered to immunodeficient mice engrafted with in vitro cell model of human adrenocortical carcinoma (ACC). Here, we developed and validated a zebrafish model engrafted with cortisol-secreting ACC cells to study the effects of AbiAc on tumor growth.
Adrenocortical carcinoma xenograft in zebrafish embryos as model to study the in vivo cytotoxicity of abiraterone acetate
Gianoncelli, Alessandra;Guarienti, Michela;Fragni, Martina;Bertuzzi, Michela;Rossini, Elisa;Abate, Andrea;Basnet, Ram M;Zizioli, Daniela;Bono, Federica;Memo, Maurizio;Berruti, Alfredo;Sigala, Sandra
2019-01-01
Abstract
Abiraterone acetate (AbiAc) inhibits tumor growth when administered to immunodeficient mice engrafted with in vitro cell model of human adrenocortical carcinoma (ACC). Here, we developed and validated a zebrafish model engrafted with cortisol-secreting ACC cells to study the effects of AbiAc on tumor growth.File in questo prodotto:
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