Purpose : Proliferative diabetic retinopathy (PDR), a major complication of diabetes mellitus, represents the main cause of blindness in the Western world. PDR results from the imbalance of pro- and anti-angiogenic factors, being VEGF the most relevant player. Nevertheless, limitations to anti-VEGF therapies do exist and the local production of other growth factors may affect the response to drug treatment. In this frame, PDR vitreous samples may provide information for a better understanding of the pathogenesis of the disease and used for preclinical evaluation of novel drug candidates.
The vitreous humor from proliferative diabetic retinopathy patients: translational implications
S RezzolaWriting – Original Draft Preparation
;MI NawazWriting – Review & Editing
;A CancariniMembro del Collaboration Group
;F SemeraroFunding Acquisition
;M PrestaProject Administration
2019-01-01
Abstract
Purpose : Proliferative diabetic retinopathy (PDR), a major complication of diabetes mellitus, represents the main cause of blindness in the Western world. PDR results from the imbalance of pro- and anti-angiogenic factors, being VEGF the most relevant player. Nevertheless, limitations to anti-VEGF therapies do exist and the local production of other growth factors may affect the response to drug treatment. In this frame, PDR vitreous samples may provide information for a better understanding of the pathogenesis of the disease and used for preclinical evaluation of novel drug candidates.File in questo prodotto:
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The vitreous humor from proliferative diabetic retinopathy patients_ translational implications _ IOVS _ ARVO Journals.pdf
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Descrizione: Vitreous PDR, Inv Ophth, 2019
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