The dynamic, fluid-filled RCCS™ bioreactor, based on the operational principle of relative micro-gravity condition, is a new efficient system devised to perform long-term three-dimensional (3D) culture of cells and tissue explants. In the present study, we evaluated the impact of the RCCS™-produced hydrodynamic condition on an innovative 3D in vitro model of osteocytes’ differentiation and bone matrix formation, obtained by coupling primary human osteoblasts with biphasic calcium phosphate (BCP) ceramic particles.
Impact of the dynamic culture condition in the RCCS™ bioreactor on a three-dimensional model of bone formation
MAZZOLENI, Giovanna;STEIMBERG, Nathalie;
2011-01-01
Abstract
The dynamic, fluid-filled RCCS™ bioreactor, based on the operational principle of relative micro-gravity condition, is a new efficient system devised to perform long-term three-dimensional (3D) culture of cells and tissue explants. In the present study, we evaluated the impact of the RCCS™-produced hydrodynamic condition on an innovative 3D in vitro model of osteocytes’ differentiation and bone matrix formation, obtained by coupling primary human osteoblasts with biphasic calcium phosphate (BCP) ceramic particles.File in questo prodotto:
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