The dynamic, fluid-filled RCCS™ bioreactor, based on the operational principle of relative micro-gravity condition, is a new efficient system devised to perform long-term three-dimensional (3D) culture of cells and tissue explants. In the present study, we evaluated the impact of the RCCS™-produced hydrodynamic condition on an innovative 3D in vitro model of osteocytes’ differentiation and bone matrix formation, obtained by coupling primary human osteoblasts with biphasic calcium phosphate (BCP) ceramic particles.

Impact of the dynamic culture condition in the RCCS™ bioreactor on a three-dimensional model of bone formation

MAZZOLENI, Giovanna;STEIMBERG, Nathalie;
2011-01-01

Abstract

The dynamic, fluid-filled RCCS™ bioreactor, based on the operational principle of relative micro-gravity condition, is a new efficient system devised to perform long-term three-dimensional (3D) culture of cells and tissue explants. In the present study, we evaluated the impact of the RCCS™-produced hydrodynamic condition on an innovative 3D in vitro model of osteocytes’ differentiation and bone matrix formation, obtained by coupling primary human osteoblasts with biphasic calcium phosphate (BCP) ceramic particles.
File in questo prodotto:
File Dimensione Formato  
Procedia Engineering 2011.pdf

gestori archivio

Tipologia: Full Text
Licenza: DRM non definito
Dimensione 2.33 MB
Formato Adobe PDF
2.33 MB Adobe PDF   Visualizza/Apri   Richiedi una copia

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11379/98308
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 10
  • ???jsp.display-item.citation.isi??? 8
social impact