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2009 AUG 5. [EPUB AHEAD OF PRINT]

Serum levels of brain-derived neurotrophic factor in drug-naïve obsessive-compulsive patients: A case-control study.

GENNARELLI, Massimo;
2010-01-01

Abstract

2009 AUG 5. [EPUB AHEAD OF PRINT]
2010
Altre Amm. Pubb. Italiane
LS5_11 Neurological disorders (e.g. Alzheimer's disease, Huntington's disease, Parkinson's disease)
JOURNAL OF AFFECTIVE DISORDERS
2-s2.0-77649182475
WOS:000276980200025
Inglese
122
174
178
Background: There is lack of data regarding BDNF serum levels in patients with obsessive–compulsive disorder (OCD). The aims of the present study were: 1) to assess the serum BDNF content in a sample of drug-naïve patients with OCD and 2) to assess whether putative alterations in peripheral BDNF may be associated to OCD severity and clinical characteristics. Methods: Twenty-four drug-naïve patients with a principal diagnosis of OCD were recruited. In parallel, a control group of 24 unrelated volunteers matched for gender and age was enrolled. Serum BDNF levels were measured by ELISA method. Results: The results showed that BDNF levels were decreased in OCD patients when compared to controls (36.90±6.42 ng/ml versus 41.59±7.82 ng/ml; p=0.043). No correlations were evidenced between serumBDNF content and the severity of OCD symptomsmeasured as Y-BOCS scores or other clinical variables. Limitations: The choice of drug-naïve patientswith obsessive–compulsive disorder had limited the size of the sample and excluded the recruitment of patients with a severe symptomatology. Conclusions: Our findings reveal for the first time in OCD patients a decrease in serumBDNF levels. These data corroborate the hypothesis of a dysfunction in the neurotrophin expression in the OCD pathogenetic mechanism and provide the rationale for further investigations directed to the identification of novel biomarkers and new therapeutic strategies for antiobsessional treatments.
Sogg. privati ital. no profit
6
info:eu-repo/semantics/article
262
Maina, G; Rosso, G; Zanardini, R; Bogetto, F; Gennarelli, Massimo; BOCCHIO CHIAVETTO, L.
1 Contributo su Rivista::1.1 Articolo in rivista
none
1.1 Articolo in rivista
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11379/8617
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