CD4+ and CD8+ Lymphocytes of Patients with AIDS Synthesize Increased Amounts of Interferon-gamma.

Caruso, A.; Canaris, A. D.; Licenziati, S.; Cantalamessa, A.; Folghera, S.; Lonati, M. A.; De Panfilis, G.; Turano, Adolfo

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Individual cells capable of interferon-γ/(IFN-γ) synthesis are easily detected by immunofluorescence and flow cytometric analysis using an anti- IFN-γ monoclonal antibody as specific reagent. By IFN-γ flow cytometry assay, we demonstrated that HIV-seropositive patients, starting at the early stage of viral infection, generally have an increased percentage of lymphocytes potentially able to produce IFN-γ, compared with healthy blood donors, IFN-γ expression in patient lymphocytes was observed to increase with the progressive stages of HIV infection, with the highest figures occurring in stage C patients. Such increased IFN-γ expression involved both CD4+ and CD8+ T cell subsets. Most interestingly, we found patients at the same stage of HIV infection who had similar numbers of total and CD4+ lymphocytes but highly different percentages of lymphocytes potentially capable of producing IFN-γ.

Titolo:	CD4+ and CD8+ Lymphocytes of Patients with AIDS Synthesize Increased Amounts of Interferon-gamma.
Autori:	CARUSO, Arnaldo CANARIS A. D. LICENZIATI S. CANTALAMESSA A. FOLGHERA S. LONATI M. A. DE PANFILIS G. TURANO, Adolfo mostra contributor esterni nascondi contributor esterni
Data di pubblicazione:	1995
Rivista:	JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES AND HUMAN RETROVIROLOGY
Abstract:	Individual cells capable of interferon-γ/(IFN-γ) synthesis are easily detected by immunofluorescence and flow cytometric analysis using an anti- IFN-γ monoclonal antibody as specific reagent. By IFN-γ flow cytometry assay, we demonstrated that HIV-seropositive patients, starting at the early stage of viral infection, generally have an increased percentage of lymphocytes potentially able to produce IFN-γ, compared with healthy blood donors, IFN-γ expression in patient lymphocytes was observed to increase with the progressive stages of HIV infection, with the highest figures occurring in stage C patients. Such increased IFN-γ expression involved both CD4+ and CD8+ T cell subsets. Most interestingly, we found patients at the same stage of HIV infection who had similar numbers of total and CD4+ lymphocytes but highly different percentages of lymphocytes potentially capable of producing IFN-γ.
Handle:	http://hdl.handle.net/11379/8187
Appare nelle tipologie:	1.1 Articolo in rivista

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