Multimorbidity and fluid biomarkers of Alzheimer's disease: a systematic review

Aim: This review aimed to summarize the evidence on the association between multimorbidity and levels of CSF and blood biomarkers of Alzheimer´s disease. Findings: Most studies on blood biomarkers of Alzheimer’s disease reported an association between multimorbidity and elevated biomarker levels. The studies on CSF biomarkers found mixed results. Message: Given the heterogeneity of studies and participant characteristics, future research should focus on including older populations with higher multimorbidity burden and examining both CSF and blood biomarkers simultaneously to better understand their interrelations and implications for AD diagnosis and treatment.