Infectious complications are a significant cause of morbidity and mortality in patients undergoing allogeneic haematopoietic stem cell transplantation (Allo-SCT). The BATMO (Best-Antimicrobial-Therapy-TMO) is an innovative program for infection prevention and management and has been used in our centre since 2019. The specific features of the BATMO protocol regard both prophylaxis during neutropenia (abandonment of fluoroquinolone, posaconazole use in high-risk patients, aerosolized liposomal amphotericin B use until engraftment or a need for antifungal treatment, and letermovir use in CMV-positive recipients from day 0 to day +100) and therapy (empirical antibiotics based on patient clinical history and colonization, new antibiotics used in second-line according to antibiogram with the exception of carbapenemase-producing K pneumoniae for which the use in first-line therapy is chosen).

Results of an Innovative Program for Surveillance, Prophylaxis, and Treatment of Infectious Complications Following Allogeneic Stem Cell Transplantation in Hematological Malignancies (BATMO Protocol)

Malagola, Michele
Conceptualization
;
Turra, Alessandro
Membro del Collaboration Group
;
Signorini, Liana
Membro del Collaboration Group
;
Corbellini, Silvia
Membro del Collaboration Group
;
Polverelli, Nicola
Membro del Collaboration Group
;
Masina, Lorenzo
Membro del Collaboration Group
;
Del Fabro, Giovanni
Membro del Collaboration Group
;
Lorenzotti, Silvia
Membro del Collaboration Group
;
Fumarola, Benedetta
Membro del Collaboration Group
;
Farina, Mirko
Membro del Collaboration Group
;
Morello, Enrico
Membro del Collaboration Group
;
Radici, Vera
Membro del Collaboration Group
;
Buttini, Eugenia Accorsi
Membro del Collaboration Group
;
Colnaghi, Federica
Membro del Collaboration Group
;
Bernardi, Simona
Membro del Collaboration Group
;
Re, Federica
Membro del Collaboration Group
;
Caruso, Arnaldo
Membro del Collaboration Group
;
Castelli, Francesco
Membro del Collaboration Group
;
Russo, Domenico
Membro del Collaboration Group
2022

Abstract

Infectious complications are a significant cause of morbidity and mortality in patients undergoing allogeneic haematopoietic stem cell transplantation (Allo-SCT). The BATMO (Best-Antimicrobial-Therapy-TMO) is an innovative program for infection prevention and management and has been used in our centre since 2019. The specific features of the BATMO protocol regard both prophylaxis during neutropenia (abandonment of fluoroquinolone, posaconazole use in high-risk patients, aerosolized liposomal amphotericin B use until engraftment or a need for antifungal treatment, and letermovir use in CMV-positive recipients from day 0 to day +100) and therapy (empirical antibiotics based on patient clinical history and colonization, new antibiotics used in second-line according to antibiogram with the exception of carbapenemase-producing K pneumoniae for which the use in first-line therapy is chosen).
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11379/559719
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