Infectious complications are a significant cause of morbidity and mortality in patients undergoing allogeneic haematopoietic stem cell transplantation (Allo-SCT). The BATMO (Best-Antimicrobial-Therapy-TMO) is an innovative program for infection prevention and management and has been used in our centre since 2019. The specific features of the BATMO protocol regard both prophylaxis during neutropenia (abandonment of fluoroquinolone, posaconazole use in high-risk patients, aerosolized liposomal amphotericin B use until engraftment or a need for antifungal treatment, and letermovir use in CMV-positive recipients from day 0 to day +100) and therapy (empirical antibiotics based on patient clinical history and colonization, new antibiotics used in second-line according to antibiogram with the exception of carbapenemase-producing K pneumoniae for which the use in first-line therapy is chosen).
Results of an Innovative Program for Surveillance, Prophylaxis, and Treatment of Infectious Complications Following Allogeneic Stem Cell Transplantation in Hematological Malignancies (BATMO Protocol)
Malagola, MicheleConceptualization
;Turra, AlessandroMembro del Collaboration Group
;Signorini, LianaMembro del Collaboration Group
;Corbellini, SilviaMembro del Collaboration Group
;Polverelli, NicolaMembro del Collaboration Group
;Masina, LorenzoMembro del Collaboration Group
;Del Fabro, GiovanniMembro del Collaboration Group
;Lorenzotti, SilviaMembro del Collaboration Group
;Fumarola, BenedettaMembro del Collaboration Group
;Farina, MirkoMembro del Collaboration Group
;Morello, EnricoMembro del Collaboration Group
;Radici, VeraMembro del Collaboration Group
;Buttini, Eugenia AccorsiMembro del Collaboration Group
;Colnaghi, FedericaMembro del Collaboration Group
;Bernardi, SimonaMembro del Collaboration Group
;Re, FedericaMembro del Collaboration Group
;Caruso, ArnaldoMembro del Collaboration Group
;Castelli, FrancescoMembro del Collaboration Group
;Russo, DomenicoMembro del Collaboration Group
2022-01-01
Abstract
Infectious complications are a significant cause of morbidity and mortality in patients undergoing allogeneic haematopoietic stem cell transplantation (Allo-SCT). The BATMO (Best-Antimicrobial-Therapy-TMO) is an innovative program for infection prevention and management and has been used in our centre since 2019. The specific features of the BATMO protocol regard both prophylaxis during neutropenia (abandonment of fluoroquinolone, posaconazole use in high-risk patients, aerosolized liposomal amphotericin B use until engraftment or a need for antifungal treatment, and letermovir use in CMV-positive recipients from day 0 to day +100) and therapy (empirical antibiotics based on patient clinical history and colonization, new antibiotics used in second-line according to antibiogram with the exception of carbapenemase-producing K pneumoniae for which the use in first-line therapy is chosen).I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
