Five new polyketides were isolated from the rare filamentous fungusAspergillus californicusIBT 16748 including calidiol A (1); three phthalide derivatives califuranones A1, A2, and B (2-4); and a pair of enantiomers (−)-calitetralintriol A (−5) and (+)-calitetralintriol A (+5) together with four known metabolites (6-9). The structures of the new products were established by extensive spectroscopic analyses including HRMS and 1D and 2D NMR. The absolute configurations of two diastereomers2and3and the enantiomers (−5) and (+5) were assigned by comparing their experimental and calculated ECD data, whereas the absolute configuration of4was proposed by analogy. Compound1showed moderate activity against methicillin-resistantStaphylococcus aureus.
Taxonomy Driven Discovery of Polyketides fromAspergillus californicus
Ghidinelli S.;
2021-01-01
Abstract
Five new polyketides were isolated from the rare filamentous fungusAspergillus californicusIBT 16748 including calidiol A (1); three phthalide derivatives califuranones A1, A2, and B (2-4); and a pair of enantiomers (−)-calitetralintriol A (−5) and (+)-calitetralintriol A (+5) together with four known metabolites (6-9). The structures of the new products were established by extensive spectroscopic analyses including HRMS and 1D and 2D NMR. The absolute configurations of two diastereomers2and3and the enantiomers (−5) and (+5) were assigned by comparing their experimental and calculated ECD data, whereas the absolute configuration of4was proposed by analogy. Compound1showed moderate activity against methicillin-resistantStaphylococcus aureus.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
