Dosage compensation for X chromosome-linked genes is achieved in female mammals by the transcriptional inactivation of one of the two X chromosomes during embryogenesis. The mechanism by which thousands of genes on only one of a pair of apparently identical chromosomes is turned off represents one of the most fascinating problems in mammalian genetics. Recent data, including the identification of a gene (XIST) exclusively expressed by the inactive X chromosome, may open the way to the understanding of the molecular mechanisms underlying X chromosome inactivation. © 1993 Academic Press. All rights reserved.

X chromosome gene dosage compensation in female mammals

Borsani G.
Writing – Original Draft Preparation
;
1993-01-01

Abstract

Dosage compensation for X chromosome-linked genes is achieved in female mammals by the transcriptional inactivation of one of the two X chromosomes during embryogenesis. The mechanism by which thousands of genes on only one of a pair of apparently identical chromosomes is turned off represents one of the most fascinating problems in mammalian genetics. Recent data, including the identification of a gene (XIST) exclusively expressed by the inactive X chromosome, may open the way to the understanding of the molecular mechanisms underlying X chromosome inactivation. © 1993 Academic Press. All rights reserved.
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11379/540111
 Attenzione

Attenzione! I dati visualizzati non sono stati sottoposti a validazione da parte dell'ateneo

Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 12
  • ???jsp.display-item.citation.isi??? ND
social impact