Dosage compensation for X chromosome-linked genes is achieved in female mammals by the transcriptional inactivation of one of the two X chromosomes during embryogenesis. The mechanism by which thousands of genes on only one of a pair of apparently identical chromosomes is turned off represents one of the most fascinating problems in mammalian genetics. Recent data, including the identification of a gene (XIST) exclusively expressed by the inactive X chromosome, may open the way to the understanding of the molecular mechanisms underlying X chromosome inactivation. © 1993 Academic Press. All rights reserved.
X chromosome gene dosage compensation in female mammals
Borsani G.Writing – Original Draft Preparation
;
1993-01-01
Abstract
Dosage compensation for X chromosome-linked genes is achieved in female mammals by the transcriptional inactivation of one of the two X chromosomes during embryogenesis. The mechanism by which thousands of genes on only one of a pair of apparently identical chromosomes is turned off represents one of the most fascinating problems in mammalian genetics. Recent data, including the identification of a gene (XIST) exclusively expressed by the inactive X chromosome, may open the way to the understanding of the molecular mechanisms underlying X chromosome inactivation. © 1993 Academic Press. All rights reserved.File in questo prodotto:
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