IRIS Institutional Research Information System - OPENBS Open Archive UniBS

Management of loco-regionally advanced squamous laryngeal cancer in elderly patients

Cesare Piazza;
2020-01-01
2020
EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
2-s2.0-85087781678
WOS:000547807100002
Inglese
32656672
Purpose: To describe the management and outcomes of loco-regionally advanced (stages III-IV) laryngeal cancer (LRALC) in elderly patients. Methods: Clinical records of 88 LRALC patients treated at our Institution from 2002 to 2017 were retrospectively reviewed. Patients were divided in 2 subgroups: age > 65 years (elderly) and age ≤ 65 years (controls). Survivals were estimated with Kaplan-Meier method and compared with log-rank test, multivariate analysis were performed with Cox proportional hazard methods. Results: Eighty-eight LRALC patients were included: 45 elderly and 43 controls. Median follow-up was 55.3 months. Median age was 66 years (range 41-84) in the overall population, 72 years (range 66-84) in the elderly cohort. The majority (98%) of elderly patients had at least one comorbidity (ACE27 1-3), while ACE27 was 0 in 37% of controls (p = 0.0001). ECOG PS was 0 in 42% of elderly vs 79% of controls (p = 0.0029). Clinical stage (TNM eighth edition) was III in 67%, IVA in 22% and IVB in 11%. Treatment consisted in total laryngectomy (TL) in 55%, chemo-radiation in 29%, exclusive radiotherapy in 9%, and conservative surgery in 7%. In elderly patients 2-year disease-free and overall survivals were 58% and 74%, respectively. Multivariate analysis performed on the overall group of 88 patients showed that age (HR 1.07, p = 0.0006) and TNM (for both 7th and 8th Editions HR 0.27 for stage III vs IV, p = 0.0005) maintained an independent statistical significant association with OS. Conclusions: In this monocentric cohort, age and TNM confirmed their independent prognostic role in LRALC patients. Organ-preservation is still an unmet need in a significant portion of elderly patients.
Elderly; Head and neck; Laryngeal cancer; Prognostic factor
18
info:eu-repo/semantics/article
262
Cavalieri, Stefano; Orlandi, Ester; Ivaldi, Eliana; Bergamini, Cristiana; Alfieri, Salvatore; Alessandro Iacovelli, Nicola; Ingargiola, Rossana; Reste...espandi
1 Contributo su Rivista::1.1 Articolo in rivista
reserved
1.1 Articolo in rivista
File in questo prodotto:
File Dimensione Formato  
Management of loco-regionally advanced.pdf

gestori archivio

Tipologia: Full Text
Licenza: DRM non definito
Dimensione 728.12 kB
Formato Adobe PDF
  Visualizza/Apri   Richiedi una copia
728.12 kB Adobe PDF   Visualizza/Apri   Richiedi una copia

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11379/533793
 Attenzione

Attenzione! I dati visualizzati non sono stati sottoposti a validazione da parte dell'ateneo

Citazioni
  • ???jsp.display-item.citation.pmc??? 3
  • Scopus 3
  • ???jsp.display-item.citation.isi??? 3
social impact