The effect of oxidants on PTP opening has been widely reported, yet the targets are unknown. Here, Carraro et al. identify OSCP C141 of F-ATP synthase as a target of oxidants regulating the PTP. Cyclophilin D binding to OSCP has a protective effect and prevents PTP opening induced by oxidants.
The Unique Cysteine of F-ATP Synthase OSCP Subunit Participates in Modulation of the Permeability Transition Pore
Schiavone M.Investigation
;
2020-01-01
Abstract
The effect of oxidants on PTP opening has been widely reported, yet the targets are unknown. Here, Carraro et al. identify OSCP C141 of F-ATP synthase as a target of oxidants regulating the PTP. Cyclophilin D binding to OSCP has a protective effect and prevents PTP opening induced by oxidants.File in questo prodotto:
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