The effect of oxidants on PTP opening has been widely reported, yet the targets are unknown. Here, Carraro et al. identify OSCP C141 of F-ATP synthase as a target of oxidants regulating the PTP. Cyclophilin D binding to OSCP has a protective effect and prevents PTP opening induced by oxidants.

The Unique Cysteine of F-ATP Synthase OSCP Subunit Participates in Modulation of the Permeability Transition Pore

Schiavone M.
Investigation
;
2020-01-01

Abstract

The effect of oxidants on PTP opening has been widely reported, yet the targets are unknown. Here, Carraro et al. identify OSCP C141 of F-ATP synthase as a target of oxidants regulating the PTP. Cyclophilin D binding to OSCP has a protective effect and prevents PTP opening induced by oxidants.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11379/533141
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