Several studies showed high serum copper levels in Alzheimer’s disease (AD). The present study applied a newly developed method to detect serum copper free from proteins (free-Cu). Forty-four patients affected by dementia due to AD, thirty-six patients affected by mild cognitive impairment (MCI) due to AD, and twenty-eight healthy controls underwent clinical, cognitive, and MRI assessment. The new method showed higher free-Cu concentrations in MCI and dementia due to AD compared to controls (p < 0.0001). No correlation between copper levels, cognitive or MRI measures were found.

Serum Non-Ceruloplasmin Non-Albumin Copper Elevation in Mild Cognitive Impairment and Dementia due to Alzheimer’s Disease: A Case Control Study

Rozzini, Luca;LANFRANCHI, FRANCESCO;Pilotto, Andrea;Catalani, Simona;Gilberti, Maria Enrica;Paganelli, Matteo;Apostoli, Pietro;Padovani, Alessandro
2018-01-01

Abstract

Several studies showed high serum copper levels in Alzheimer’s disease (AD). The present study applied a newly developed method to detect serum copper free from proteins (free-Cu). Forty-four patients affected by dementia due to AD, thirty-six patients affected by mild cognitive impairment (MCI) due to AD, and twenty-eight healthy controls underwent clinical, cognitive, and MRI assessment. The new method showed higher free-Cu concentrations in MCI and dementia due to AD compared to controls (p < 0.0001). No correlation between copper levels, cognitive or MRI measures were found.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11379/501123
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