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Motor function, olfactory threshold and hematological indices in manganese exposed ferroalloy workers.

LUCCHINI, Roberto;APOSTOLI, Pietro
1997-01-01
1997
Ateneo di appartenenza
LS7_5 Toxicology
LS7_10 Public health and epidemiology
ENVIRONMENTAL RESEARCH
2-s2.0-0031127434
WOS:A1997XY13500020
Sì, ma tipo non specificato
Inglese
Internazionale
73
175
180
Abstract A cross-sectional study was conducted in 35 male subjects randomly selected from workers of a ferroalloy production plant and exposed to manganese (Mn) oxides; the objective was to detect early signs of neurologic impairment. The subjects' mean age was 39.4 years (SD, 8.4); the average exposure duration was 14.5 years (range, 5–29 years). A control group of industrial workers not exposed to neurotoxic chemicals and comparable in age and confounding factors was recruited. The intensity of Mn exposure was moderate, as reflected by airborne Mn concentrations in total dust averaging 193 μg/m3. Mn levels in blood (MnB) and urine (MnU) were significantly higher in the Mn-exposed workers than in control workers. A relationship (not found with MnU) was found between MnB and a cumulative exposure index calculated on the basis of air concentration and exposure history for each subject (r= 0.52;r2= 0.27;P= 0.002). Psychomotor function scores were lower among Mn-exposed subjects. The Aiming score was negatively correlated with MnB in the exposed group. The olfactory threshold did not differ between the two groups, although it was negatively associated with MnU in the exposed group. The white blood cell count results were significantly higher in Mn-exposed subjects than in controls. These findings show that an increase in Mn body burden is associated with an impairment of motor functions, whereas the increased excretion of Mn is related to an increased olfactory perception. Changes in numbers of leukocytes could indicate possible interferences of Mn with the immunological system.
Air Pollutants; Occupational exposure; behavior; Humans; Male; Manganese
Altra università italiana
4
info:eu-repo/semantics/article
262
Lucchini, Roberto; Bergamaschi, E; Smargiassi, A; Apostoli, Pietro
1 Contributo su Rivista::1.1 Articolo in rivista
none
1.1 Articolo in rivista
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11379/4859
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