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Long-Term Calorie Restriction Enhances Cellular Quality-Control Processes in Human Skeletal Muscle

FONTANA, Luigi
2016-01-01
2016
2015
Altre fonti
LS4_5 Metabolism, biological basis of metabolism related disorders
CELL REPORTS
sì
2-s2.0-84953227268
WOS:000368701600003
Esperti anonimi
Inglese
Internazionale
ELETTRONICO
14
3
422
428
7
26774472
Calorie restriction (CR) retards aging, acts as a hormetic intervention, and increases serum corticosterone and HSP70 expression in rodents. However, less is known regarding the effects of CR on these factors in humans. Serum cortisol and molecular chaperones and autophagic proteins were measured in the skeletal muscle of subjects on CR diets for 3-15 years and in control volunteers. Serum cortisol was higher in the CR group than in age-matched sedentary and endurance athlete groups (15.6 ± 4.6 ng/dl versus 12.3 ± 3.9 ng/dl and 11.2 ± 2.7 ng/dl, respectively; p ≤ 0.001). HSP70, Grp78, beclin-1, and LC3 mRNA and/or protein levels were higher in the skeletal muscle of the CR group compared to controls. Our data indicate that CR in humans is associated with sustained rises in serum cortisol, reduced inflammation, and increases in key molecular chaperones and autophagic mediators involved in cellular protein quality control and removal of dysfunctional proteins and organelles.
Aldosterone; Autophagy; Calorie restriction; Cortisol; HSP70; Biochemistry, Genetics and Molecular Biology (all)
Altre fonti
http://www.sciencedirect.com/science/journal/22111247
sì
11
info:eu-repo/semantics/article
262
Yang, Ling; Licastro, Danilo; Cava, Edda; Veronese, Nicola; Spelta, Francesco; Rizza, Wanda; Bertozzi, Beatrice; Villareal, Dennis T.; Hotamisligil, G...espandi
1 Contributo su Rivista::1.1 Articolo in rivista
none
1.1 Articolo in rivista
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11379/478562
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