Lack of robust predictive biomarkers, other than MGMT promoter methylation, makes temozolomide responsiveness in newly diagnosed glioblastoma (GBM) patients difficult to predict. However, we identified patients with long-term survival (≥35 months) within a group of newly diagnosed GBM patients treated with standard or metronomic adjuvant temozolomide schedules. We thus investigated possible molecular profiles associated with longer survival following temozolomide treatment.
EGFR amplified and overexpressing glioblastomas and association with better response to adjuvant metronomic temozolomide
COMINELLI, Manuela;GRISANTI, Salvatore;BRANCA, Caterina;BUGLIONE DI MONALE E BASTIA, Michela;FACCHETTI, Fabio;PIZZI, Marina;POLIANI, Pietro Luigi
2015-01-01
Abstract
Lack of robust predictive biomarkers, other than MGMT promoter methylation, makes temozolomide responsiveness in newly diagnosed glioblastoma (GBM) patients difficult to predict. However, we identified patients with long-term survival (≥35 months) within a group of newly diagnosed GBM patients treated with standard or metronomic adjuvant temozolomide schedules. We thus investigated possible molecular profiles associated with longer survival following temozolomide treatment.File in questo prodotto:
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