Background The objective of this study was to assess survival, prognostic factors, and complications in a cohort of patients with intestinal-type adenocarcinoma (ITAC) treated with transnasal endoscopic surgery (ES) ± radiotherapy [RT]. Methods Patients with ITAC who underwent ES ± RT at two tertiary centers were retrospectively reviewed. Overall (OS) and event-free (EFS) survivals were calculated, and statistically significant variables were entered in a multivariate Cox regression model. Complications were also analyzed. Results One-hundred-sixty-nine patients were included. Major complications occurred in 9.5% of patients. Adjuvant RT was delivered in 58.6% of patients. Five-year OS and EFS were 68.9% and 63.6%, respectively. Advanced pT classification, high grade, and positive surgical margins were independently predictive of poor survival. Conclusions ES ± RT is a valid treatment option in most cases of ITAC. When compared with series based on external surgery, our results support a definitive paradigm shift in the management of ITAC.

Intestinal type adenocarcinoma of the ethmoid: Outcomes of a treatment regimen based on endoscopic surgery with or without radiotherapy.

NICOLAI, Piero;DONATO, Francesco;TURRI ZANONI, Mario;
2015

Abstract

Background The objective of this study was to assess survival, prognostic factors, and complications in a cohort of patients with intestinal-type adenocarcinoma (ITAC) treated with transnasal endoscopic surgery (ES) ± radiotherapy [RT]. Methods Patients with ITAC who underwent ES ± RT at two tertiary centers were retrospectively reviewed. Overall (OS) and event-free (EFS) survivals were calculated, and statistically significant variables were entered in a multivariate Cox regression model. Complications were also analyzed. Results One-hundred-sixty-nine patients were included. Major complications occurred in 9.5% of patients. Adjuvant RT was delivered in 58.6% of patients. Five-year OS and EFS were 68.9% and 63.6%, respectively. Advanced pT classification, high grade, and positive surgical margins were independently predictive of poor survival. Conclusions ES ± RT is a valid treatment option in most cases of ITAC. When compared with series based on external surgery, our results support a definitive paradigm shift in the management of ITAC.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11379/461570
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