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Age-dependent, seasonal and daily variations of the DNA damaging capacity of the hepatocarcinogen ZAMI 1305 in female rat liver.

PRESTA, Marco;MAZZOLENI, Giovanna;
1984-01-01
1984
Enti pubb. di ricerca ital.
LS1_2 General biochemistry and metabolism
LS4_8 Non-communicable diseases (except for neural/psychiatric, immunity-related, metabolism-related disorders, cancer and cardiovascular diseases)
LS1_1 Molecular biology and interactions
CANCER LETTERS
sì
2-s2.0-0021216275
WOS:A1984TE79900002
Sì, ma tipo non specificato
Inglese
Internazionale
23
245
251
6
6744248
A single injection of the sex-dependent hepatocarcinogen DL-1-(2-nitro-3-methyl-phenoxy)-3-tert-butylamino-propan-2-ol (ZAMI 1305) caused age-related DNA damage, as evaluated by alkaline sucrose gradient analysis, in the liver of female Wistar rats. DNA damage reached a maximum at 4-6 weeks of age, about the onset of sexual maturity, and decreased thereafter. In young rats (5-8 weeks of age), the amount of ZAMI 1305-induced DNA damage showed seasonal and daily differences, being higher when the molecule was administered in winter in respect to summer and in the evening in respect to the morning. In older rats (15-22 weeks of age), no seasonal and daily variations were observed.
Aging; Animals; Carcinogens; Circadian Rhythm; DNA; Female; Liver; Organ Size; Propanolamines; Rats; Seasons; Sexual Maturation
MIUR (compresi PRIN FIRB,FISR)
6
info:eu-repo/semantics/article
262
S., Ziliani; Presta, Marco; C., Mazzocchi; Mazzoleni, Giovanna; D., Calovini; G., Ragnotti
1 Contributo su Rivista::1.1 Articolo in rivista
none
1.1 Articolo in rivista
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11379/32334
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