IRIS Institutional Research Information System - OPENBS Open Archive UniBS

Effects of somatostatin analogs on glucose homeostasis: a metaanalysis of acromegaly studies.

MAZZIOTTI, Gherardo;BONADONNA, Stefania;GIUSTINA, Andrea
2009-01-01
2009
Ateneo di appartenenza
LS4_3 Endocrinology
LS4_5 Metabolism, biological basis of metabolism
THE JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
2-s2.0-66149122229
WOS:000265851500004
Inglese
94
1500
1508
8
19208728
BACKGROUND: Somatostatin analogs (SSA) may influence glucose metabolism, but the clinical relevance of this effect is uncertain because trials performed so far are limited in terms of number of patients and heterogeneity for length and type of follow-up. PURPOSE: The purpose of the study was to assess, via the metaanalysis of acromegaly studies, the clinical impact of SSA on glucose metabolism. The outcomes analyzed were fasting plasma glucose, fasting plasma insulin, hemoglobin A(1c), and plasma glucose concentrations during oral glucose tolerance test. STUDY SELECTION: Eligibility criteria were: 1) duration of SSA treatment of at least 3 wk; 2) available numerical data for at least one of the four biochemical outcomes investigated; 3) measurement of the outcomes before and after SSA treatment; and 4) no selection of acromegalic patients for their responsivity to SSA. After revision, only 31 studies fulfilled eligibility criteria and were therefore selected for data extraction and analysis. DATA SYNTHESIS: SSA treatment was found to induce statistically significant decrease in fasting plasma insulin [effect size -0.45, 95\% confidence interval (CI) from -0.58 to -0.32, P < 0.001], without any significant change of fasting plasma glucose (effect size +0.04, 95\% CI from -0.07 to +0.15, P = 0.52) and hemoglobin A(1c) (effect size +0.11, 95\% CI from -0.02 to +0.23, P = 0.09). Serum glucose values during the oral glucose tolerance test were shown to significantly change during SSA treatment (effect size +0.31, 95\% CI from +0.17 to +0.45, P < 0.001), although with high inconsistency among trials. CONCLUSIONS: Our data suggest that modifications of glucose homeostasis induced by SSA may have an overall minor clinical impact in acromegaly.
Acromegaly; Adult; Blood Glucose; Female; Glucose; Hemoglobin A; Glycosylated; Homeostasis; Hormone Antagonists; Humans; Insulin; Male; Randomized Controlled Trials as Topic; Regression Analysis; Somatostatin
http://dx.doi.org/10.1210/jc.2008-2332
6
info:eu-repo/semantics/article
262
Mazziotti, Gherardo; Floriani, I; Bonadonna, Stefania; Torri, V; Chanson, P; Giustina, Andrea
1 Contributo su Rivista::1.1 Articolo in rivista
none
1.1 Articolo in rivista
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11379/31925
Citazioni
  • ???jsp.display-item.citation.pmc??? 99
  • Scopus 198
  • ???jsp.display-item.citation.isi??? 174
social impact