IRIS Institutional Research Information System - OPENBS Open Archive UniBS

Genetic Variation in the G720/G30 Gene Locus (DAOA) Influences the Occurrence of Psychotic Symptoms in Patients with Alzheimer's Disease.

GENNARELLI, Massimo
2009-01-01
2009
Altre Amm. Pubb. Italiane
LS2_6 Molecular genetics, reverse genetics and RNAi
JOURNAL OF ALZHEIMER'S DISEASE
2-s2.0-74949121348
WOS:000272863500019
Inglese
18
953
960
7
20009237
The occurrence of neuropsychiatric symptoms in patients with Alzheimer's disease hampers the clinical management and exacerbates the burden for caregivers. To what extent psychotic symptoms are genetically determined and which are the genes involved has to be established. We tested the hypothesis that the occurrence of delusions and hallucinations in AD is associated with variations in the G72/DAOA gene, which is supposed to play a key role in the glutamate pathway regulated through the NMDA receptors. A panel of single nucleotide polymorphisms were genotyped in a cohort of 185 Alzheimer's disease patients. The analysis demonstrated a nominally significant association (p< 0.05) with one single nucleotide polymorphism (rs2153674). In addition, multivariate regression showed that the rs2153674 genotype accounts for up to 15\% of the variance in delusions severity, as assessed by using the Neuropsychiatric Inventory. If the results from the present study will be replicated, the glutamate hypothesis could be invoked to explain the occurrence of psychosis in neurodegenerative disorders.
Sogg. privati ital. no profit
http://dx.doi.org/10.3233/JAD-2009-1194
6
info:eu-repo/semantics/article
262
E. D., Maria; C., Bonvicini; C., Bonomini; A., Alberici; O., Zanetti; Gennarelli, Massimo
1 Contributo su Rivista::1.1 Articolo in rivista
reserved
1.1 Articolo in rivista
File in questo prodotto:
File Dimensione Formato  
Di Maria JAD 2009 DAOA e BPSD.PDF

gestori archivio

Tipologia: Full Text
Licenza: DRM non definito
Dimensione 371.86 kB
Formato Adobe PDF
  Visualizza/Apri   Richiedi una copia
371.86 kB Adobe PDF   Visualizza/Apri   Richiedi una copia

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11379/31372
Citazioni
  • ???jsp.display-item.citation.pmc??? 16
  • Scopus 25
  • ???jsp.display-item.citation.isi??? 23
social impact