IRIS Institutional Research Information System - OPENBS Open Archive UniBS

Cholesterol atheromatous embolism: an increasingly recognized cause of acute renal failure.

SCOLARI, Francesco;BONARDELLI, Stefano;MAIORCA, Rosario
1996-01-01
1996
Ateneo di appartenenza
LS7_7 Surgery
LS7_6 Gene therapy, stem cell therapy, regenerative medicine
NEPHROLOGY DIALYSIS TRANSPLANTATION
2-s2.0-8944223511
WOS:A1996VC62900026
Inglese
11
1607
1612
5
8856220
BACKGROUND: Cholesterol atheromatous embolism is a systemic disease resulting from cholesterol crystal embolization to many organs, including the kidney. Vascular surgery, vascular radiology investigations and anticoagulation have been identified as inciting factors. METHODS: Fifteen patients with extensive atherosclerosis, presenting with simultaneous occurrence of acute renal failure and peripheral ischaemic changes were diagnosed as having acute renal failure due to cholesterol atheromatous embolism. RESULTS: The patients, 12 men and three women, had an average age of 65 years. In one patient, spontaneous occurrence of the disease was observed. An inciting factor was identified in 14 patients: aortography in 10, aortic surgery in two, and thrombolysis in two. Clinical course of acute renal failure was quite variable. Four patients required dialysis; 11 were conservatively managed. All patients had concomitant skin lesions, including digital mottling, cyanosis and gangrene of the toes, and livedo reticularis of the lower limb and abdomen. Eosinophilia was the most common laboratory abnormality. The diagnosis of cholesterol atheromatous embolism was confirmed by tissue examination in eight; in three it was based on the finding of retinal cholesterol emboli; in four patients it was made on clinical grounds. Seven patients died within 36 months. Death was most commonly from cardiac causes. CONCLUSIONS: Since the population at risk for cholesterol embolism is growing and the disease is iatrogenic in origin, we should expect to detect cholesterol embolism with greater frequency as cause of acute renal failure in the future.
Aged; Arteriosclerosis; Embolism; Cholesterol; Female; Humans; Kidney; Kidney Failure; Acute; Male; Middle Aged; Skin
10
info:eu-repo/semantics/article
262
Scolari, Francesco; M., Bracchi; B., Valzorio; E., Movilli; E., Costantino; S., Savoldi; S., Zorat; Bonardelli, Stefano; R., Tardanico; Maiorca, Rosar...espandi
1 Contributo su Rivista::1.1 Articolo in rivista
none
1.1 Articolo in rivista
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11379/30992
Citazioni
  • ???jsp.display-item.citation.pmc??? 16
  • Scopus 95
  • ???jsp.display-item.citation.isi??? 79
social impact