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Early and long-term prognostic factors after liver resection for HCC.

PORTOLANI, Nazario;CONIGLIO, Arianna;TIBERIO, Guido Alberto Massimo;
1999-01-01
1999
Ateneo di appartenenza
LS7_6 Gene therapy, stem cell therapy, regenerative medicine
LS7_7 Surgery
CHIRURGIA ITALIANA
2-s2.0-0033182249
Inglese
51
335
343
8
10738606
The Authors discuss the principal early and long term predictive factors after liver resection in patients with hepatocellular carcinoma (HCC). The Authors report (131 cases) early mortality as 7.6%, entirely confined in the group, numerically prevalent and affected by cirrhosis. None of the 50 patients with chronic hepatitis (29 cases) or normal liver (21 cases) died after hepatic resection. Mortality is higher in Child B patients (20.7%) and in cases in which a massive haemotransfusion was given (p < 0.05), apart from the width of resection and from the number of hepatic resections. None of 41 cirrhotic Child A patients undergoing a limited hepatic resection (< or = 1 segment) died during the perioperative period. In the group of patients which survived to the resection, global survival at 5 years was 45%. The most important prognostic factor is local recurrence while cirrhosis and the degree of liver failure are not statistically significant. No feature can identify a subgroup of patients with a higher risk of recurrence, which is observed in 52% of patients with a follow up observation after more than 1 year. Among the 29 patients alive after more than 4 years from liver resection, only 11 didn't have local recurrence. The others were treated with iterative hepatic resections or with radiological techniques. In conclusion, the present experience suggests that, in selected cases, hepatic resection could be a low risk therapy (in cirrhotic patients as well). The long term results could improve with an aggressive attitude towards recurrence.
Adult; Aged; 80 and over; Carcinoma; Hepatocellular; Female; Follow-Up Studies; Hepatectomy; Humans; Liver Neoplasms; Male; Middle Aged; Postoperative Complications; Prognosis; Survival Rate; Time Factors
no
8
info:eu-repo/semantics/article
262
Portolani, Nazario; M., Ronconi; S., Ghidoni; G., Gaverini; Coniglio, Arianna; Tiberio, Guido Alberto Massimo; F., Nodari; S. M., Giulini
1 Contributo su Rivista::1.1 Articolo in rivista
none
1.1 Articolo in rivista
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11379/30878
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