OBJECTIVE: To assess the effect of repetitive transcranial magnetic stimulation (rTMS) to the dorsolateral prefrontal cortex (DLPFC) on picture naming in patients with Alzheimer disease (AD). DESIGN: Experimental study. Patients with AD underwent rTMS in real and control conditions during picture-naming tasks. SETTING: San Giovanni di Dio Fatebenefratelli Scientific Institute in Brescia, Italy. Patients Fifteen patients with probable AD. Intervention High-frequency rTMS was applied to the left and right DLPFC during object and action naming. MAIN OUTCOME MEASURES: Language ability was assessed by accuracy of verbal response during online rTMS. RESULTS: Stimulation to the left and right DLPFC improved accuracy in action naming. CONCLUSIONS: These findings indicate that rTMS to the DLPFC, which speeds up action naming in normal controls, improves performance in patients with AD. While the mechanisms of rTMS-induced naming facilitation in these patients are unknown, the procedure may be worth testing as a novel approach to the treatment of language dysfunction.
Effect of transcranial magnetic stimulation on action naming in patients with Alzheimer disease
MINIUSSI, Carlo
2006-01-01
Abstract
OBJECTIVE: To assess the effect of repetitive transcranial magnetic stimulation (rTMS) to the dorsolateral prefrontal cortex (DLPFC) on picture naming in patients with Alzheimer disease (AD). DESIGN: Experimental study. Patients with AD underwent rTMS in real and control conditions during picture-naming tasks. SETTING: San Giovanni di Dio Fatebenefratelli Scientific Institute in Brescia, Italy. Patients Fifteen patients with probable AD. Intervention High-frequency rTMS was applied to the left and right DLPFC during object and action naming. MAIN OUTCOME MEASURES: Language ability was assessed by accuracy of verbal response during online rTMS. RESULTS: Stimulation to the left and right DLPFC improved accuracy in action naming. CONCLUSIONS: These findings indicate that rTMS to the DLPFC, which speeds up action naming in normal controls, improves performance in patients with AD. While the mechanisms of rTMS-induced naming facilitation in these patients are unknown, the procedure may be worth testing as a novel approach to the treatment of language dysfunction.File | Dimensione | Formato | |
---|---|---|---|
ArchNeruol_Cotelli_06.pdf
gestori archivio
Tipologia:
Documento in Post-print
Licenza:
DRM non definito
Dimensione
77.31 kB
Formato
Adobe PDF
|
77.31 kB | Adobe PDF | Visualizza/Apri Richiedi una copia |
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.