Objective: Relationships between the apolipoprotein E 4 allele and electroencephalographic (EEG) rhythmicity have been demonstrated in Alzheimer’s disease (AD) patients but not in the preclinical stage prodromic to it, namely, mild cognitive impairment (MCI). The present multicentric EEG study tested the hypothesis that presence of 4 affects sources of resting EEG rhythms in both MCI and AD subjects. Methods: We enrolled 89 MCI subjects (34.8% with 4) and 103 AD patients (50.4% with 4). Resting eyes-closed EEG data were recorded for all subjects. EEG rhythms of interest were delta (2—4Hz), theta (4–8Hz), alpha 1 (8–10.5Hz), alpha 2 (10.5–13Hz), beta 1 (13–20Hz), and beta 2 (20–30Hz). EEG cortical sources were estimated by low-resolution brain electromagnetic tomography. Results: Results showed that amplitude of alpha 1 and 2 sources in occipital, temporal, and limbic areas was lower in subjects carrying the 4 allele than in those not carrying the 4 allele (p < 0.01). This was true for both MCI and AD. For the first time to our knowledge, a relationship was shown between ApoE genotype and global neurophysiological phenotype (ie, cortical alpha rhythmicity) in a preclinical AD condition, MCI, in addition to clinically manifest AD. Interpretation: Such a demonstration motivates future genotype–EEG phenotype studies for the early prediction of AD conversion in individual MCI subjects.

Apolipoprotein E and alpha brain rhythms in mild cognitive impairment: A multicentric Electroencephalogram study

MINIUSSI, Carlo;
2006-01-01

Abstract

Objective: Relationships between the apolipoprotein E 4 allele and electroencephalographic (EEG) rhythmicity have been demonstrated in Alzheimer’s disease (AD) patients but not in the preclinical stage prodromic to it, namely, mild cognitive impairment (MCI). The present multicentric EEG study tested the hypothesis that presence of 4 affects sources of resting EEG rhythms in both MCI and AD subjects. Methods: We enrolled 89 MCI subjects (34.8% with 4) and 103 AD patients (50.4% with 4). Resting eyes-closed EEG data were recorded for all subjects. EEG rhythms of interest were delta (2—4Hz), theta (4–8Hz), alpha 1 (8–10.5Hz), alpha 2 (10.5–13Hz), beta 1 (13–20Hz), and beta 2 (20–30Hz). EEG cortical sources were estimated by low-resolution brain electromagnetic tomography. Results: Results showed that amplitude of alpha 1 and 2 sources in occipital, temporal, and limbic areas was lower in subjects carrying the 4 allele than in those not carrying the 4 allele (p < 0.01). This was true for both MCI and AD. For the first time to our knowledge, a relationship was shown between ApoE genotype and global neurophysiological phenotype (ie, cortical alpha rhythmicity) in a preclinical AD condition, MCI, in addition to clinically manifest AD. Interpretation: Such a demonstration motivates future genotype–EEG phenotype studies for the early prediction of AD conversion in individual MCI subjects.
File in questo prodotto:
File Dimensione Formato  
AnnOfNeurol_Babiloni_06.pdf

gestori archivio

Tipologia: Documento in Post-print
Licenza: DRM non definito
Dimensione 1.37 MB
Formato Adobe PDF
1.37 MB Adobe PDF   Visualizza/Apri   Richiedi una copia

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11379/26002
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 92
  • ???jsp.display-item.citation.isi??? ND
social impact