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Association between IL-1beta -511C/T and IL-1RA (86bp)n repeats polymorphisms and schizophrenia.

GENNARELLI, Massimo
2003-01-01
2003
Altre Amm. Pubb. Italiane
LS2_6 Molecular genetics, reverse genetics and RNAi
JOURNAL OF PSYCHIATRIC RESEARCH
sì
2-s2.0-0141955231
WOS:000186239700014
Sì, ma tipo non specificato
Inglese
Internazionale
37
457
462
It has been established that cytokines play a critical role in the regulation of the CNS and recent studies have suggested that dysfunctions of both pro-inflammatory (IL-1b, IL-6, and TNF-a) and anti-inflammatory (IL-1RA and IL-10) cytokines could be involved in the pathophysiology of schizophrenia. Previous studies have reported that functional polymorphisms in some cytokines genes may have important regulatory effects on such system. Therefore, the aim of the present study was to explore the possible role of the IL-1b -511C/T and IL-1RA (86bp)n repeats polymorphisms in schizophrenia. A case control association study comparing genotype and allele frequencies in 346 northen Italian subjects (169 schizophrenic patients and 177 unrelated healthy volunteers) was performed. The frequencies of IL-1b -511C and IL-1RA allele 1 (86bp)4 are significantly higher in schizophrenic patients compared to controls (IL-1b -511 P=0.047; IL-1RA (86bp)n P=0.002). Moreover our data show a protective effect of the IL-1RA allele 2 (86bp)2 against schizophrenia (OR=0.59 95%CI:0.388–0.910; P=0.016) and this effect is enhanced by the concomitant presence of IL-1b -511T (OR=0.48 95%CI:0.30-0.76; P=0.002). Our findings support the hypothesis that genetically determined changes in IL-1 metabolism regulation may contribute to the pathogenesis of schizophrenia confirming a role of IL-1 gene cluster in disease susceptibility.
Sogg. privati ital. no profit
8
info:eu-repo/semantics/article
262
Zanardini, R; Bocchiochiavetto, L; Scassellati, C; Bonvicini, C; Tura, Gb; Rossi, G; Perez, J; Gennarelli, Massimo
1 Contributo su Rivista::1.1 Articolo in rivista
none
1.1 Articolo in rivista
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11379/22079
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