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Promoter haplotypes of interleukin-10 gene and sporadic Alzheimer's disease.

GENNARELLI, Massimo
2004-01-01
2004
Altre Amm. Pubb. Italiane
LS2_6 Molecular genetics, reverse genetics and RNAi
LS5_11 Neurological disorders (e.g. Alzheimer's disease, Huntington's disease, Parkinson's disease)
NEUROSCIENCE LETTERS
sì
2-s2.0-1642554417
WOS:000188742400012
Sì, ma tipo non specificato
Inglese
Internazionale
356(2)
119
122
Clinical and immunopathological evidence support a potential role of the pro- and anti-inflammatory cytokine network in neurodegeneration of Alzheimer’s disease (AD). Moreover, association studies suggest a possible involvement of cytokine-related genes in the susceptibility to sporadic AD. Since conflicting results are associated with the pro-inflammatory pathway, we investigated a putative effect of the anti-inflammatory counterpart focusing on the interleukin-10 (IL-10) gene. The 50 flanking region contains numerous polymorphisms; in particular, three single nucleotide polymorphisms (21082 G/A, 2819 T/C, 2592 C/A) are in linkage disequilibrium resulting in three haplotypes GCC, ACC and ATA. We analyzed the IL-10 haplotype distributions in 215 Italian sporadic AD patients and 153 controls in an association case-control study. Haplotype frequencies did not reveal differences between the two samples, however the genotype GCC/ACC was more represented in AD patients (OR 1.91, 95% CI: 1.18–3.07). This putative risk factor could be independent of the presence of the ApoE 14 allele. Our results provide new insights on a possible involvement of the IL-10 gene in susceptibility to sporadic AD even though further functional and genetic investigations are necessary to clarify its role in AD.
Sogg. privati ital. no profit
9
info:eu-repo/semantics/article
262
Scassellati, C; Zanardini, R; Squitti, R; BOCCHIO CHIAVETTO, L; Bonvicini, C; Binetti, G; Zanetti, O; Cassetta, E; Gennarelli, Massimo
1 Contributo su Rivista::1.1 Articolo in rivista
none
1.1 Articolo in rivista
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11379/21956
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