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No association between Ala9Val functional polymorphism of MnSOD gene and schizophrenia in a representative Italian sample.

GENNARELLI, Massimo
2006-01-01
2006
Altre Amm. Pubb. Italiane
LS2_6 Molecular genetics, reverse genetics and RNAi
NEUROSCIENCE LETTERS
2-s2.0-33750975649
WOS:000243092200012
Inglese
Internazionale
410
208
211
Reactive oxygen species (ROS) have been suggested to play an important role in physiopathology of schizophrenia. The polymorphisms in the genes encoding antioxidant enzymes, such as manganese superoxide dismutase (MnSOD) should, thus, result in predisposition to this psychiatric disorder.Afunctional amino acid polymorphism (Ala9Val) has been described in the signal sequence of enzyme associated with a decreased defense capacity against oxidative stress. Preliminary evidence in a Turkey population indicated that this polymorphism contributes to physiopathogenesis of schizophrenia. The object of this study was to verify the association between Ala9Val and schizophrenia in a representative Italian sample. The polymorphism was genotyped by PCR amplification and Single-Stranded Conformational Polymorphism (SSCP) analysis in 212 DSMIV schizophrenic patients and 257 healthy volunteers. No association was observed between cases and controls (genotype and allele frequencies: p = 0.72, p = 0.55, respectively) even when a sample stratification for gender, age at onset and diagnostic subtypes was performed. This suggests that the gene variant could not be a risk factor for schizophrenia susceptibility in an Italian sample.
8
info:eu-repo/semantics/article
262
Ventriglia, M; Scassellati, C; Bonvicini, C; Squitti, R; Bevacqua, Mg; Foresti, G; Tura, Gb; Gennarelli, Massimo
1 Contributo su Rivista::1.1 Articolo in rivista
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1.1 Articolo in rivista
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11379/21890
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