Objectives: The aim of this study was to investigate the effects of soy-derived isoflavones on hot flushes and vascular reactivity of Uterine Arteries (UA), Internal Carotid Arteries (ICA), Middle Cerebral Arteries (MCA), in post- menopausal women. Materials and methods: This study was a double-blind placebo-controlled randomised trial. 58 postmenopausal Italian women aged between 45 and 60 years entered the study. They all were free from any major illness and com- plained of at least seven hot flushes daily. 28 of them were treated with two tablets daily containing 36mg of soy- derived isoflavones, each. The other 30 patients were treated with two placebo tablets daily. All patients kept a daily diary of hot flushes. Patients were evaluated at basal time, after three months and after six months. At each control time the number of hot flushes was recorded and an_ultrasound scan was performed together with a doppler evaluation of uter- ine and cerebral arteries. Results: The daily mean number of hot flushes at basal time was 9.7 in both groups. After the first month we observed a significant decrease to 6.2 in the soy group and 5.6 in place- bo group. However, no differences were observed between the two groups. This reduction was maintained for both groups till the end of the study. Conclusions: The treatment with soy-derived isoflavones causes a reduction of hot flushes not different from that due to placebo.

EFFECTS OF SOY-DERIVED ISOFLAVONES ON HOT FLUSHES AND VASCULAR REACTIVITY

OMODEI, Umberto;
2002-01-01

Abstract

Objectives: The aim of this study was to investigate the effects of soy-derived isoflavones on hot flushes and vascular reactivity of Uterine Arteries (UA), Internal Carotid Arteries (ICA), Middle Cerebral Arteries (MCA), in post- menopausal women. Materials and methods: This study was a double-blind placebo-controlled randomised trial. 58 postmenopausal Italian women aged between 45 and 60 years entered the study. They all were free from any major illness and com- plained of at least seven hot flushes daily. 28 of them were treated with two tablets daily containing 36mg of soy- derived isoflavones, each. The other 30 patients were treated with two placebo tablets daily. All patients kept a daily diary of hot flushes. Patients were evaluated at basal time, after three months and after six months. At each control time the number of hot flushes was recorded and an_ultrasound scan was performed together with a doppler evaluation of uter- ine and cerebral arteries. Results: The daily mean number of hot flushes at basal time was 9.7 in both groups. After the first month we observed a significant decrease to 6.2 in the soy group and 5.6 in place- bo group. However, no differences were observed between the two groups. This reduction was maintained for both groups till the end of the study. Conclusions: The treatment with soy-derived isoflavones causes a reduction of hot flushes not different from that due to placebo.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11379/166614
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