Purpose of review. To describe the incidence, major risk factors, and the clinical, electrophysiological, and histological features of critical illness myopathy (CIM). Major pathogenetic mechanisms and long-term consequences of CIM are also reviewed. Recent findings. CIM is frequently associated with critical illness polyneuropathy (CIP), and may have a relevant impact on patients’ outcome. CIM has an earlier onset than CIP, and recovery is faster. Loss of myosin filaments on muscle biopsy is important to diagnose CIM, and has a good prognosis. Critical illness, use of steroids, and immobility concur in causing CIM. Summary. A rationale diagnostic approach to CIM using clinical, electrophysiological, and muscle biopsy investigations is important to plan adequate therapy and to predict recovery.

Critical illness myopathy

LATRONICO, Nicola;Filosto M.
2012-01-01

Abstract

Purpose of review. To describe the incidence, major risk factors, and the clinical, electrophysiological, and histological features of critical illness myopathy (CIM). Major pathogenetic mechanisms and long-term consequences of CIM are also reviewed. Recent findings. CIM is frequently associated with critical illness polyneuropathy (CIP), and may have a relevant impact on patients’ outcome. CIM has an earlier onset than CIP, and recovery is faster. Loss of myosin filaments on muscle biopsy is important to diagnose CIM, and has a good prognosis. Critical illness, use of steroids, and immobility concur in causing CIM. Summary. A rationale diagnostic approach to CIM using clinical, electrophysiological, and muscle biopsy investigations is important to plan adequate therapy and to predict recovery.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11379/165696
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