Met-enkephalin immunoreactive material content was found to be decreased in the cervical and thoracic segments of the spinal cord from rats aged 25 months as comparedto young, 3-month -old rats. No age-related variations were detectable at the lumbar level. Bio_Gel P30 column chromatographyof thoracic segments extracts indicates that the composition of the immunoreactive material is similar in the two age-groups investigated. At the thoracic level opiate receptor binding was also measured. Opiate receptor number is increased in the thoracic segments of the spinal cord of older rats. These age-related changes in immunoreactive Met-enkephalin content and opiate receptor number at spinal levels may contribute to determine an altered pain sensitivity during aging.

Age-related changes of enkephalin in rat spinal cord

MISSALE, Mariacristina;SPANO, Pier Franco;
1983

Abstract

Met-enkephalin immunoreactive material content was found to be decreased in the cervical and thoracic segments of the spinal cord from rats aged 25 months as comparedto young, 3-month -old rats. No age-related variations were detectable at the lumbar level. Bio_Gel P30 column chromatographyof thoracic segments extracts indicates that the composition of the immunoreactive material is similar in the two age-groups investigated. At the thoracic level opiate receptor binding was also measured. Opiate receptor number is increased in the thoracic segments of the spinal cord of older rats. These age-related changes in immunoreactive Met-enkephalin content and opiate receptor number at spinal levels may contribute to determine an altered pain sensitivity during aging.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11379/155355
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