MALNUTRITION INFLAMMATION SCORE AND RISK OF HOSPITALISATION AND MORTALITY IN PERITONEAL DIALYSIS PATIENTS.

Background. Protein-energy wasting (PEW) represents the state of metabolic and nutritional alteration due to dietetic and non-dietetic factors. Cumulative evidence suggests that PEW is strongly associated with the increasing risk of morbidity and mortality. The aim of the study was to evaluate the association between nutritional status and number of hospitalization and mortality in Peritoneal Dialysis patients. Methods. Nutritional status was assessed with Malnutrition Inflammation Score (MIS) in two times: the follow-up was minimum 6 months for both evaluations and maximum 1 year for the first one and 8 months for the second one. Both MIS were correlated with number of hospitalization and number of death. Results. A total of 80 patients underwent the assessment of nutritional status: the first evaluation (MIS1) includes 38 patients (mean age 64.9±14.9), the second one (MIS2) includes 67 patients (mean age 65.76±14.5). 29% of patients in MIS1 and 31% in MIS2 had moderate PEW, 18% in MIS1 and 4% in MIS2 had severe PEW. There was a significant correlation between nutritional status and number of hospitalizations only in the second evaluation: higher MIS (worst nutritional status) was related to a major number of hospitalizations (p<0.05) than patients with good nutritional status. Furthermore, higher MIS (worst nutritional status) was related to more number of deaths in both evaluations (p<0.001 and p<0.01). Conclusion. MIS can be used as a screening nutritional test and can predict the risk of short-term mortality and hospitalizations in PD patients.