SPANO, Pier Franco
 Distribuzione geografica
Continente #
NA - Nord America 13.197
EU - Europa 8.925
AS - Asia 3.517
OC - Oceania 28
AF - Africa 22
SA - Sud America 22
Continente sconosciuto - Info sul continente non disponibili 21
Totale 25.732
Nazione #
US - Stati Uniti d'America 13.130
PL - Polonia 3.199
CN - Cina 2.318
UA - Ucraina 2.031
DE - Germania 972
IT - Italia 765
FI - Finlandia 477
FR - Francia 469
GB - Regno Unito 414
HK - Hong Kong 384
IN - India 329
IE - Irlanda 313
SG - Singapore 271
VN - Vietnam 100
SE - Svezia 74
BE - Belgio 63
CA - Canada 63
RU - Federazione Russa 48
TR - Turchia 41
CZ - Repubblica Ceca 36
IR - Iran 33
AU - Australia 24
EU - Europa 21
KR - Corea 19
MU - Mauritius 18
CH - Svizzera 17
NL - Olanda 15
CL - Cile 9
ES - Italia 9
BR - Brasile 8
IL - Israele 5
RO - Romania 5
JP - Giappone 4
NZ - Nuova Zelanda 4
MX - Messico 3
AR - Argentina 2
BA - Bosnia-Erzegovina 2
BD - Bangladesh 2
BG - Bulgaria 2
BO - Bolivia 2
EE - Estonia 2
ET - Etiopia 2
GE - Georgia 2
MK - Macedonia 2
PT - Portogallo 2
SK - Slovacchia (Repubblica Slovacca) 2
TH - Thailandia 2
AM - Armenia 1
AZ - Azerbaigian 1
GR - Grecia 1
HR - Croazia 1
HU - Ungheria 1
LU - Lussemburgo 1
LV - Lettonia 1
OM - Oman 1
PA - Panama 1
PE - Perù 1
PK - Pakistan 1
SA - Arabia Saudita 1
SI - Slovenia 1
SL - Sierra Leone 1
TM - Turkmenistan 1
TW - Taiwan 1
ZA - Sudafrica 1
Totale 25.732
Città #
Warsaw 3.199
Fairfield 1.716
Woodbridge 1.712
Jacksonville 1.480
Houston 1.002
Ashburn 912
Ann Arbor 831
Cambridge 721
Chandler 719
Wilmington 655
Seattle 648
Princeton 588
Nanjing 572
Dearborn 406
Hong Kong 382
Dublin 311
Beijing 303
Brescia 301
Helsinki 210
New York 206
Nanchang 204
Singapore 171
Shenyang 160
Des Moines 143
Pune 138
Tianjin 131
Hebei 126
Changsha 119
Jinan 116
Dong Ket 100
Lancaster 97
San Diego 84
Milan 81
Jiaxing 79
Shanghai 73
Kunming 69
Brussels 61
Verona 48
Hangzhou 46
London 46
Ningbo 44
Los Angeles 39
Taizhou 38
Toronto 38
Zhengzhou 34
Munich 33
San Francisco 33
San Mateo 31
Haikou 30
Ardabil 29
Augusta 29
Boardman 29
Brno 28
Lanzhou 28
Monmouth Junction 27
Kocaeli 26
Guangzhou 25
Leawood 24
Orange 20
Changchun 19
Norwalk 18
Rome 18
Fuzhou 17
Basel 16
Hefei 14
Kilburn 14
Ottawa 14
Phoenix 14
San Donà Di Piave 14
Romola 12
Taiyuan 11
Canberra 9
Madrid 8
Nürnberg 8
Teramo 8
Auburn Hills 7
Melbourne 7
New Bedfont 7
Olomouc 7
Redwood City 7
Seoul 6
Vicenza 6
Acton 5
Bologna 5
Chicago 5
Chions 5
Clifton 5
Hanover 5
Mumbai 5
Redmond 5
Santa Clara 5
Bergamo 4
Chiswick 4
Dallas 4
Fulda 4
Hounslow 4
Oxford 4
Sydney 4
São Paulo 4
Torino 4
Totale 19.893
Nome #
CHF5074 (CSP-1103) induces microglia alternative activation in plaque-free Tg2576 mice and primary glial cultures exposed to beta-amyloid 306
Neuroprotective and Anti-Apoptotic Effects of CSP-1103 in Primary Cortical Neurons Exposed to Oxygen and Glucose Deprivation 271
PEA and luteolin synergistically reduce mast cell-mediated toxicity and elicit neuroprotection in cell-based models of brain ischemia 264
Glutamatergic neurons induce expression of functional glutamatergic synapses in primary myotubes. 260
Ropinirole and Pramipexole Promote Structural Plasticity in Human iPSC-Derived Dopaminergic Neurons via BDNF and mTOR Signaling 260
Redistribution of DAT/α-synuclein complexes visualized by “in situ” proximity ligation assay in transgenic mice modelling early Parkinson’s disease 250
Glutamatergic Reinnervation and Assembly of Glutamatergic Synapses in Adult Rat Skeletal Muscle Occurs at Cholinergic Endplates 247
Glutamatergic reinnervation through peripheral nerve graft dictates assembly of glutamatergic synapses at rat skeletal muscle 246
1B/(-)IRE DMT1 Expression during Brain Ischemia Contributes to Cell Death Mediated by NF-κB/RelA Acetylation at Lys310 235
GPNMB/OA protein increases the invasiveness of human metastatic prostate cancer cell lines DU145 and PC3 through MMP-2 and MMP-9 activity 231
The End Is the Beginning: Parkinson's Disease in the Light of Brain Imaging 227
NF-κB in Innate Neuroprotection and Age-Related Neurodegenerative Diseases 225
NF-κB and epigenetic mechanisms as integrative regulators of brain resilience to anoxic stress. 223
Priming of cultured neurons with sabeluzole results in long-lasting inhibition of neurotoxin-induced tau expression and cell death. 220
The Contribution of -Synuclein Spreading to Parkinson’s Disease Synaptopathy 220
Late-onset Parkinsonism in NFκB/c-Rel-deficient mice. 215
Synergistic association of valproate and resveratrol reduces brain injury in ischemic stroke 215
Nicotine-induced structural plasticity in mesencephalic dopaminergic neurons is mediated by dopamine d3 receptors and akt-mtorc1 signaling 213
Targeted acetylation of NF-kappaB/RelA and histones by epigenetic drugs reduces post-ischemic brain injury in mice with an extended therapeutic window. 212
Mild inflammatory profile without gliosis in the c-rel deficient mouse modeling a late-onset parkinsonism 211
Mitochondria and alpha-synuclein: Friends or foes in the pathogenesis of Parkinson's disease? 170
NUOVO IMPIEGO TERAPEUTICO PREVENTIVO DELLA SUBUNITA' C-REL DELLA PROTEINA NF-KAPPAB E NUOVO IMPIEGO DI UN ANIMALE TRASGENICO NON UMANO CHE PORTA LA DELEZIONE DEL GENE C-REL (C-REL-/-) 161
The "in situ" proximity ligation assay to probe protein-protein interactions in intact tissues 157
The gamma-Secretase Modulator CHF5074 Reduces the Accumulation of Native Hyperphosphorylated Tau in a Transgenic Mouse Model of Alzheimer's Disease 154
Role of Dopamine D2/D3 Receptors in Development, Plasticity, and Neuroprotection in Human iPSC-Derived Midbrain Dopaminergic Neurons 154
Synapsin III is a key component of α-synuclein fibrils in Lewy bodies of PD brains 153
Spinal cord mGlu1a receptors - Possible target for amyotrophic lateral sclerosis therapy 147
Targeting IKK2 by pharmacological inhibitor AS602868 prevents excitotoxic injury to neurons and oligodendrocytes. 147
Post-ischemic brain damage: NF-kappaB dimer heterogeneity as a molecular determinant of neuron vulnerability 143
NF-kappaB p50/RelA and c-Rel-containing dimers: opposite regulators of neuron vulnerability to ischaemia. 142
c-Rel deficient mice, a mouse model of "spreading" PD-like pathology. 142
Bim and Noxa are candidates to mediate the deleterious effect of the NF-kappa B subunit RelA in cerebral ischemia. 141
Targeting of Disordered Proteins by Small Molecules in Neurodegenerative Diseases 135
Different muscarinic receptor subtypes modulate proliferation of primary human detrusor smooth muscle cells via Akt/PI3K and map kinases. 135
Chapter 24 NF-KappaB Dimers in the Regulation of Neuronal Survival 133
An Integrated Approach for a Structural and Functional Evaluation of Biosimilars: Implications for Erythropoietin 130
Inhibition of Survivin Is Associated with Zoledronic Acid-induced Apoptosis of Prostate Cancer Cells 126
Structural plasticity in mesencephalic dopaminergic neurons produced by drugs of abuse: critical role of BDNF and dopamine 125
Age-related changes of enkephalin in rat spinal cord 123
Cellular mechanisms for neurotensin receptor-mediated release of prolactin. 123
Identification and characterization of a kappa B/Rel binding site in the regulatory region of the amyloid precursor protein gene. 122
mGluR5 metabotropic glutamate receptor distribution in rat and human spinal cord: a developmental study. 119
Expression of functional NR1/NR2B-type NMDA receptors in neuronally differentiated SK-N-SH human cell line 117
A new pharmacological approach to the facilitation of acetylcholine transmission. 116
Alpha-synuclein aggregation and cell death triggered by energy deprivation and dopamine overload are counteracted by D2/D3 receptor activation 115
Differential effects of caffeine on dihydroxyphenylacetic acid concentrations in various rat brain dopaminergic structures 111
The proximity ligation assay: an high throughput technique for protein analysis in neuroscience 111
From α-synuclein to synaptic dysfunctions: new insights into the pathophysiology of Parkinson's disease 110
Induction of tumour-suppressor phosphoprotein p53 in the apoptosis of cultured rat cerebellar neurones triggered by excitatory amino acids. 109
Tau protein immunolocalization in fetal and adult human spinal cord. 108
The gamma-secretase modulator CHF5074 elicits neuroprotection and increases histone acetylation in primary cortical neurons exposed to oxygen glucose deprivation 108
Synapsin III alterations in Parkinson's disease 108
Differential gene expression of cholinergic muscarinic receptor subtypes in male and female normal human urinary bladder. 108
Dopamine receptors are present in rat and human esophagus 107
Nerve growth factor suppresses the transforming phenotype of human prolactinomas 106
Acute scopolamine treatment decreases dopamine metabolism in rat hippocampus and frontal cortex 106
SNARE protein redistribution and synaptic failure in a transgenic mouse model of Parkinson's disease. 106
The tyrosine phosphatase Shp-2 interacts with the dopamine D(1) receptor and triggers D(1) -mediated Erk signaling in striatal neurons. 106
Metabotropic glutamate receptor mRNA expression in rat spinal cord 106
Depletion of Progranulin Reduces GluN2B-Containing NMDA Receptor Density, Tau Phosphorylation, and Dendritic Arborization in Mouse Primary Cortical Neurons 106
Synergistic association of valproate and resveratrol reduces brain injury in ischemic stroke. 106
Opposing regulation of tau protein levels by ionotropic and metabotropic glutamate receptors in human NT2 neurons 105
Alpha1 adrenoceptor subtypes in human urinary bladder: sex and regional comparison. 105
Clozapine-induced alteration of glucose homeostasis in the rat: the contribution of hypothalamic-pituitary-adrenal axis activation 105
Identification of novel alternatively-spliced mRNA isoforms of metabotropic glutamate receptor 6 gene in rat and human retina. 104
Evidence for the presence of D1 and D2 dopamine receptors in the rat adrenal cortex 104
Chronic lead exposure alters dopaminergic mechanisms in rat pituitary 104
Vasoactive Intestinal Polypeptide (VIP) selectively stimulates prolactin release in healthy women 104
Mitochondrial Dysfunction and Alpha-Synuclein Synaptic Pathology in Parkinson’s Disease: Who’s on First? 104
Computational and functional analysis of biopharmaceutical drugs in zebrafish: Erythropoietin as a test model 104
Opposing roles for D-1 and D-2 dopamine receptors in the regulation of lower esophageal sphincter motility in the rat. 103
Sex-related variations in serum nerve growth factor concentration in humans. 103
The neurobiology of dopamine receptors: evolution from the dual concept to heterodimer complexes 103
SYNERGIC ROLE OF RESVERATROL AND HDACi MS-275 IN NEUROPROTECTION 103
Chronic lead exposure differentially affects dopamine transport in rat striatum and nucleus accumbens. 103
α-synuclein and synapsin III cooperatively regulate synaptic function in dopamine neurons 103
Identification of D2 dopaminergic receptors in bovine adrenal cortex. 102
Post-synaptic D1 and D2 dopamine receptors are present in rabbit renal and mesenteric arteries 102
c-Rel deficient mice, a mouse model of “spreading” PD-like pathology 102
Effect of lead exposure on dopaminergic receptors in rat striatum and nucleus accumbens 101
Nerve growth factor in the anterior pituitary: localization in mammotroph cells and co-secretion with prolactin by a dopamine-regulated mechanism 100
The miR-21/PTEN/Akt signaling pathway is involved in the anti-tumoral effects of zoledronic acid in human breast cancer cell lines 100
Prevention of neuron and oligodendrocyte degeneration by interleukin-6 (IL-6) and IL-6 receptor/IL-6 fusion protein in organotypic hippocampal slices 99
EXACERBATED AGE-DEPENDENT LOSS OF NIGRAL DOPAMINERGIC NEURONS IN NF-KAPPAB C-REL -/- MICE 99
Different neurotransmitter systems are involved in the development of esophageal achalasia 98
Evidence for the presence of both D-1 and D-2 dopamine receptors in human esophagus. 98
Nerve growth factor directs differentiation of the bipotential cell line GH-3 into the mammotroph phenotype 98
Epidermal growth factor induces the functional expression of dopamine receptors in the GH3 cell line 97
The NMDA/D1 receptor complex as a new target in drug development 97
Role of receptor heterodimers in the development of L-dopa-induced dyskinesias in the 6-hydroxydopamine rat model of Parkinson's disease. 97
Inhibition of IκBα phosphorylation prevents glutamate-induced NF-κB activation and neuronal cell death 97
Activation of NF-kappaB p65/c-Rel dimer is associated with neuroprotection elicited by mGlu5 receptor agonists against MPP(+) toxicity in SK-N-SH cells. 97
The inhibitor of IkappaBalpha phosphorylation BAY 11-7082 prevents NMDA neurotoxicity in mouse hippocampal slices. 96
Selective disarrangement of the rostral telencephalic cholinergic system in heterozygous reeler mice. 96
Dimerization of dopamine D1 and D3 receptors in the regulation of striatal function 96
Clinical Outcome After Extended Endovascular Recanalization in Buerger's Disease in 20 Consecutive Cases. 96
Angiotensin II differentially affects cyclic AMP formation in intact adrenal glomerulosa cells and in purified membrane preparations 95
Gene expression profile activated by the chemokine CCL5/RANTES in human neuronal cells 95
Nerve growth factor in pituitary development and pituitary tumors 94
Degenerazione età –dipendente dei neuroni dopaminergici della sostanza nera nei topi NF-kappaB cRel 94
Totale 13.806
Categoria #
all - tutte 113.870
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 113.870


Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2019/20206.440 0 0 295 755 431 971 780 870 487 1.102 303 446
2020/20214.303 108 520 106 542 150 489 170 532 681 321 506 178
2021/20222.375 169 525 34 90 26 71 138 137 116 310 208 551
2022/20232.035 333 35 68 175 180 584 0 192 294 26 70 78
2023/20241.962 127 36 159 126 108 461 72 84 400 31 40 318
2024/2025115 29 57 29 0 0 0 0 0 0 0 0 0
Totale 26.640