SPANO, Pier Franco
 Distribuzione geografica
Continente #
NA - Nord America 17.480
EU - Europa 10.475
AS - Asia 9.386
SA - Sud America 1.603
AF - Africa 202
OC - Oceania 31
Continente sconosciuto - Info sul continente non disponibili 22
Totale 39.199
Nazione #
US - Stati Uniti d'America 17.218
CN - Cina 3.481
PL - Polonia 3.239
SG - Singapore 3.024
UA - Ucraina 2.073
BR - Brasile 1.344
DE - Germania 1.152
IT - Italia 962
HK - Hong Kong 929
FR - Francia 766
FI - Finlandia 650
VN - Vietnam 591
GB - Regno Unito 567
IN - India 472
RU - Federazione Russa 355
TR - Turchia 326
IE - Irlanda 324
CA - Canada 143
BD - Bangladesh 136
SE - Svezia 89
AR - Argentina 77
BE - Belgio 70
MX - Messico 65
ZA - Sudafrica 64
ID - Indonesia 58
IQ - Iraq 56
NL - Olanda 47
EC - Ecuador 45
CZ - Repubblica Ceca 41
JP - Giappone 37
KR - Corea 37
IR - Iran 35
PK - Pakistan 34
ES - Italia 30
VE - Venezuela 29
KE - Kenya 27
UZ - Uzbekistan 27
AU - Australia 25
CL - Cile 25
CO - Colombia 25
CH - Svizzera 21
EU - Europa 21
PY - Paraguay 21
MA - Marocco 20
AT - Austria 19
IL - Israele 18
MU - Mauritius 18
NG - Nigeria 18
EG - Egitto 17
SA - Arabia Saudita 15
UY - Uruguay 15
JO - Giordania 12
TN - Tunisia 12
ET - Etiopia 11
PE - Perù 11
KZ - Kazakistan 10
BG - Bulgaria 9
BO - Bolivia 9
OM - Oman 9
SK - Slovacchia (Repubblica Slovacca) 9
AZ - Azerbaigian 8
JM - Giamaica 8
NP - Nepal 8
TT - Trinidad e Tobago 8
DZ - Algeria 7
PS - Palestinian Territory 7
RO - Romania 7
AE - Emirati Arabi Uniti 6
HN - Honduras 6
MY - Malesia 6
PH - Filippine 6
AL - Albania 5
CR - Costa Rica 5
DO - Repubblica Dominicana 5
GT - Guatemala 5
LT - Lituania 5
PA - Panama 5
PT - Portogallo 5
SV - El Salvador 5
TW - Taiwan 5
BA - Bosnia-Erzegovina 4
BH - Bahrain 4
EE - Estonia 4
LV - Lettonia 4
NZ - Nuova Zelanda 4
AM - Armenia 3
GE - Georgia 3
HR - Croazia 3
LK - Sri Lanka 3
MD - Moldavia 3
RS - Serbia 3
TH - Thailandia 3
TJ - Tagikistan 3
CY - Cipro 2
DK - Danimarca 2
GD - Grenada 2
GR - Grecia 2
GY - Guiana 2
KG - Kirghizistan 2
KW - Kuwait 2
Totale 39.170
Città #
Warsaw 3.234
Fairfield 1.716
Woodbridge 1.712
Singapore 1.552
Jacksonville 1.484
Ashburn 1.395
Houston 1.019
Hong Kong 927
Ann Arbor 831
Cambridge 721
Chandler 719
Seattle 664
Wilmington 657
San Jose 632
Beijing 613
Princeton 588
Nanjing 573
The Dalles 498
Dearborn 406
New York 342
Helsinki 336
Dublin 323
Brescia 314
Los Angeles 274
Istanbul 265
Lauterbourg 263
Nanchang 206
Des Moines 163
Shenyang 162
Ho Chi Minh City 161
Munich 145
Pune 141
Tianjin 140
Buffalo 131
Hebei 126
Changsha 125
Jinan 121
Milan 120
São Paulo 115
Moscow 106
Dong Ket 100
Lancaster 98
Hanoi 95
San Francisco 89
San Diego 86
Shanghai 85
Dallas 82
Jiaxing 80
Council Bluffs 79
Redondo Beach 79
London 73
Kunming 72
Santa Clara 72
Chicago 70
Orem 68
Brussels 67
Hangzhou 53
Toronto 52
Verona 52
Phoenix 48
Turku 47
Ningbo 46
Rio de Janeiro 45
Zhengzhou 42
Brooklyn 40
Guangzhou 40
Taizhou 38
Frankfurt am Main 37
Montreal 35
Rome 35
Chennai 34
Denver 34
Johannesburg 34
Augusta 33
Jakarta 33
Manchester 33
Tokyo 33
San Mateo 31
Haikou 30
Ardabil 29
Boardman 29
Lanzhou 29
Brasília 28
Brno 28
Monmouth Junction 27
Belo Horizonte 26
Kocaeli 26
Mexico City 26
Boston 25
Norwalk 25
Tashkent 25
Atlanta 24
Leawood 24
Mumbai 23
Nairobi 23
Poplar 23
Changchun 22
Dhaka 22
Haiphong 22
Orange 20
Totale 26.746
Nome #
CHF5074 (CSP-1103) induces microglia alternative activation in plaque-free Tg2576 mice and primary glial cultures exposed to beta-amyloid 371
Neuroprotective and Anti-Apoptotic Effects of CSP-1103 in Primary Cortical Neurons Exposed to Oxygen and Glucose Deprivation 365
PEA and luteolin synergistically reduce mast cell-mediated toxicity and elicit neuroprotection in cell-based models of brain ischemia 327
Ropinirole and Pramipexole Promote Structural Plasticity in Human iPSC-Derived Dopaminergic Neurons via BDNF and mTOR Signaling 322
Glutamatergic neurons induce expression of functional glutamatergic synapses in primary myotubes. 319
Targeted acetylation of NF-kappaB/RelA and histones by epigenetic drugs reduces post-ischemic brain injury in mice with an extended therapeutic window. 318
1B/(-)IRE DMT1 Expression during Brain Ischemia Contributes to Cell Death Mediated by NF-κB/RelA Acetylation at Lys310 317
Redistribution of DAT/α-synuclein complexes visualized by “in situ” proximity ligation assay in transgenic mice modelling early Parkinson’s disease 314
Glutamatergic Reinnervation and Assembly of Glutamatergic Synapses in Adult Rat Skeletal Muscle Occurs at Cholinergic Endplates 313
Priming of cultured neurons with sabeluzole results in long-lasting inhibition of neurotoxin-induced tau expression and cell death. 302
Glutamatergic reinnervation through peripheral nerve graft dictates assembly of glutamatergic synapses at rat skeletal muscle 302
NF-κB and epigenetic mechanisms as integrative regulators of brain resilience to anoxic stress. 296
GPNMB/OA protein increases the invasiveness of human metastatic prostate cancer cell lines DU145 and PC3 through MMP-2 and MMP-9 activity 296
NF-κB in Innate Neuroprotection and Age-Related Neurodegenerative Diseases 285
Late-onset Parkinsonism in NFκB/c-Rel-deficient mice. 278
Mild inflammatory profile without gliosis in the c-rel deficient mouse modeling a late-onset parkinsonism 270
The End Is the Beginning: Parkinson's Disease in the Light of Brain Imaging 264
The Contribution of -Synuclein Spreading to Parkinson’s Disease Synaptopathy 263
Synergistic association of valproate and resveratrol reduces brain injury in ischemic stroke 261
Nicotine-induced structural plasticity in mesencephalic dopaminergic neurons is mediated by dopamine d3 receptors and akt-mtorc1 signaling 260
The "in situ" proximity ligation assay to probe protein-protein interactions in intact tissues 227
NUOVO IMPIEGO TERAPEUTICO PREVENTIVO DELLA SUBUNITA' C-REL DELLA PROTEINA NF-KAPPAB E NUOVO IMPIEGO DI UN ANIMALE TRASGENICO NON UMANO CHE PORTA LA DELEZIONE DEL GENE C-REL (C-REL-/-) 218
Mitochondria and alpha-synuclein: Friends or foes in the pathogenesis of Parkinson's disease? 210
Synapsin III is a key component of α-synuclein fibrils in Lewy bodies of PD brains 208
Role of Dopamine D2/D3 Receptors in Development, Plasticity, and Neuroprotection in Human iPSC-Derived Midbrain Dopaminergic Neurons 207
An Integrated Approach for a Structural and Functional Evaluation of Biosimilars: Implications for Erythropoietin 205
Chapter 24 NF-KappaB Dimers in the Regulation of Neuronal Survival 203
The gamma-Secretase Modulator CHF5074 Reduces the Accumulation of Native Hyperphosphorylated Tau in a Transgenic Mouse Model of Alzheimer's Disease 201
NF-kappaB p50/RelA and c-Rel-containing dimers: opposite regulators of neuron vulnerability to ischaemia. 198
Bim and Noxa are candidates to mediate the deleterious effect of the NF-kappa B subunit RelA in cerebral ischemia. 198
Post-ischemic brain damage: NF-kappaB dimer heterogeneity as a molecular determinant of neuron vulnerability 197
c-Rel deficient mice, a mouse model of "spreading" PD-like pathology. 197
Targeting IKK2 by pharmacological inhibitor AS602868 prevents excitotoxic injury to neurons and oligodendrocytes. 192
Alpha-synuclein aggregation and cell death triggered by energy deprivation and dopamine overload are counteracted by D2/D3 receptor activation 192
Spinal cord mGlu1a receptors - Possible target for amyotrophic lateral sclerosis therapy 188
Inhibition of Survivin Is Associated with Zoledronic Acid-induced Apoptosis of Prostate Cancer Cells 186
The proximity ligation assay: an high throughput technique for protein analysis in neuroscience 183
Expression of functional NR1/NR2B-type NMDA receptors in neuronally differentiated SK-N-SH human cell line 182
The gamma-secretase modulator CHF5074 elicits neuroprotection and increases histone acetylation in primary cortical neurons exposed to oxygen glucose deprivation 182
Different muscarinic receptor subtypes modulate proliferation of primary human detrusor smooth muscle cells via Akt/PI3K and map kinases. 180
A new pharmacological approach to the facilitation of acetylcholine transmission. 178
Age-related changes of enkephalin in rat spinal cord 178
α-synuclein and synapsin III cooperatively regulate synaptic function in dopamine neurons 177
Identification and characterization of a kappa B/Rel binding site in the regulatory region of the amyloid precursor protein gene. 176
Depletion of Progranulin Reduces GluN2B-Containing NMDA Receptor Density, Tau Phosphorylation, and Dendritic Arborization in Mouse Primary Cortical Neurons 174
From α-synuclein to synaptic dysfunctions: new insights into the pathophysiology of Parkinson's disease 172
EXACERBATED AGE-DEPENDENT LOSS OF NIGRAL DOPAMINERGIC NEURONS IN NF-KAPPAB C-REL -/- MICE 172
c-Rel deficient mice, a mouse model of “spreading” PD-like pathology 170
Synapsin III alterations in Parkinson's disease 166
Acute scopolamine treatment decreases dopamine metabolism in rat hippocampus and frontal cortex 164
Alpha1 adrenoceptor subtypes in human urinary bladder: sex and regional comparison. 164
Targeting of Disordered Proteins by Small Molecules in Neurodegenerative Diseases 164
Activation of NF-kappaB p65/c-Rel dimer is associated with neuroprotection elicited by mGlu5 receptor agonists against MPP(+) toxicity in SK-N-SH cells. 164
Structural plasticity in mesencephalic dopaminergic neurons produced by drugs of abuse: critical role of BDNF and dopamine 163
Mitochondrial Dysfunction and Alpha-Synuclein Synaptic Pathology in Parkinson’s Disease: Who’s on First? 163
Synergistic association of valproate and resveratrol reduces brain injury in ischemic stroke. 162
Nerve growth factor suppresses the transforming phenotype of human prolactinomas 161
Cellular mechanisms for neurotensin receptor-mediated release of prolactin. 161
Should we be cautious on the use of commercially available antibodies to dopamine receptors? 161
ALPHA-SYNUCLEIN MODULATES SYNAPSIN III IN NIGROSTRIATAL DOPAMINERGIC NEURONS: IMPLICATIONS FOR PARKINSON'S DISEASE 159
Computational and functional analysis of biopharmaceutical drugs in zebrafish: Erythropoietin as a test model 157
Degenerazione età –dipendente dei neuroni dopaminergici della sostanza nera nei topi NF-kappaB cRel 155
Induction of tumour-suppressor phosphoprotein p53 in the apoptosis of cultured rat cerebellar neurones triggered by excitatory amino acids. 154
Opposing roles for D-1 and D-2 dopamine receptors in the regulation of lower esophageal sphincter motility in the rat. 154
Nerve growth factor in the anterior pituitary: localization in mammotroph cells and co-secretion with prolactin by a dopamine-regulated mechanism 154
Acetylation of NF-kappaB p50/RelA and histones in the epigenetic regulation of pro-apoptotic transcription: a neuroprotective target in brain ischemia 154
Clozapine-induced alteration of glucose homeostasis in the rat: the contribution of hypothalamic-pituitary-adrenal axis activation 153
Involvement of Synapsin III in the onset of alpha-synuclein synaptic pathology in Parkinson’s disease 153
mGluR5 metabotropic glutamate receptor distribution in rat and human spinal cord: a developmental study. 152
SYNERGIC ROLE OF RESVERATROL AND HDACi MS-275 IN NEUROPROTECTION 151
Nerve growth factor directs differentiation of the bipotential cell line GH-3 into the mammotroph phenotype 148
The miR-21/PTEN/Akt signaling pathway is involved in the anti-tumoral effects of zoledronic acid in human breast cancer cell lines 148
Lack of coupling of D2 receptors to adenylate cyclase in GH3 cells exposed to epidermal growth factor. Possible role of a differential expression of Gi protein subtypes 147
Identification of novel alternatively-spliced mRNA isoforms of metabotropic glutamate receptor 6 gene in rat and human retina. 146
Epidermal growth factor induces the functional expression of dopamine receptors in the GH3 cell line 145
Synapsin III is a key component of α-synuclein fibrils in Lewy bodies of Parkinson’s disease and dementia with Lewy bodies, 145
Ketamine enhances structural plasticity in mouse mesencephalic and human iPSC-derived dopaminergic neurons via AMPAR-driven BDNF and mTOR signaling 145
Tau protein immunolocalization in fetal and adult human spinal cord. 144
Soluble interleukin-6 (IL-6) receptor/IL-6 fusion protein enhances in vitro differentiation of purified rat oligodendroglial lineage cells. 144
An in vitro method of diagnosing Parkinson's disease 144
Inhibition of IκBα phosphorylation prevents glutamate-induced NF-κB activation and neuronal cell death 144
PGRN gene silencing in primary neuronal cultures: a model of FTLD-U 144
Dimerization of dopamine D1 and D3 receptors in the regulation of striatal function 143
Synapsin III Alteration in Parkinson's disease 143
Nerve growth factor and retinoic acid interactions in the control of small cell lung cancer proliferation. 142
Metabotropic glutamate receptor mRNA expression in rat spinal cord 141
Involvement of Synapsin III in the onset of Alpha-synuclein pathology in Parkinson’s Disease 141
A direct interaction between dopamine D1 receptor and phosphatase Shp-2 triggers Erk activation in striatal neurons 140
AAV-mediated overexpression of alpha-synuclein in midbrain dopamine neurons of Synapsin III knockout mice reveals novel molecular features involved in Parkinson's disease pathology. 140
Gene expression profile activated by the chemokine CCL5/RANTES in human neuronal cells 139
SNARE protein redistribution and synaptic failure in a transgenic mouse model of Parkinson's disease. 139
Differential effects of caffeine on dihydroxyphenylacetic acid concentrations in various rat brain dopaminergic structures 139
A soluble interleukin-6 (IL6) recepetor/IL6 fusion protein enhances the in vitro differentiation of purified rat oligodendroglial lineage cells 139
Chronic lead exposure alters dopaminergic mechanisms in rat pituitary 138
Opposing regulation of tau protein levels by ionotropic and metabotropic glutamate receptors in human NT2 neurons 137
Acute hemodynamic and neurohumoral effects of the oral dopamine derivative ibopamine in patients with heart failure. 137
Chronic lead exposure differentially affects dopamine transport in rat striatum and nucleus accumbens. 137
Synapsin III Alteration in Parkinson's disease 136
Different neurotransmitter systems are involved in the development of esophageal achalasia 135
NF-kappaB pathway: a target for preventing beta-amyloid (Abeta)-induced neuronal damage and Abeta42 production 135
Totale 19.128
Categoria #
all - tutte 175.174
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 175.174


Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2020/2021684 0 0 0 0 0 0 0 0 0 0 506 178
2021/20222.375 169 525 34 90 26 71 138 137 116 310 208 551
2022/20232.035 333 35 68 175 180 584 0 192 294 26 70 78
2023/20241.962 127 36 159 126 108 461 72 84 400 31 40 318
2024/20254.772 29 57 36 612 530 335 492 122 650 309 981 619
2025/20268.810 862 1.213 647 1.353 871 586 1.364 344 561 722 287 0
Totale 40.107