SPANO, Pier Franco
 Distribuzione geografica
Continente #
NA - Nord America 17.642
EU - Europa 10.532
AS - Asia 9.423
SA - Sud America 1.615
AF - Africa 203
OC - Oceania 31
Continente sconosciuto - Info sul continente non disponibili 22
Totale 39.468
Nazione #
US - Stati Uniti d'America 17.364
CN - Cina 3.488
PL - Polonia 3.240
SG - Singapore 3.024
UA - Ucraina 2.073
BR - Brasile 1.351
DE - Germania 1.155
IT - Italia 998
HK - Hong Kong 929
FR - Francia 769
FI - Finlandia 650
VN - Vietnam 591
GB - Regno Unito 567
IN - India 472
RU - Federazione Russa 355
TR - Turchia 326
IE - Irlanda 324
BD - Bangladesh 166
CA - Canada 156
SE - Svezia 90
AR - Argentina 78
BE - Belgio 72
MX - Messico 65
ZA - Sudafrica 64
ID - Indonesia 58
IQ - Iraq 56
NL - Olanda 48
EC - Ecuador 46
CZ - Repubblica Ceca 41
JP - Giappone 37
KR - Corea 37
IR - Iran 35
ES - Italia 34
PK - Pakistan 34
VE - Venezuela 29
CO - Colombia 27
KE - Kenya 27
UZ - Uzbekistan 27
CL - Cile 26
AU - Australia 25
CH - Svizzera 23
EU - Europa 21
PY - Paraguay 21
MA - Marocco 20
AT - Austria 19
IL - Israele 18
MU - Mauritius 18
NG - Nigeria 18
EG - Egitto 17
SA - Arabia Saudita 15
UY - Uruguay 15
JO - Giordania 12
TN - Tunisia 12
ET - Etiopia 11
PE - Perù 11
KZ - Kazakistan 10
BG - Bulgaria 9
BO - Bolivia 9
OM - Oman 9
SK - Slovacchia (Repubblica Slovacca) 9
AZ - Azerbaigian 8
JM - Giamaica 8
NP - Nepal 8
RO - Romania 8
TT - Trinidad e Tobago 8
DZ - Algeria 7
GT - Guatemala 7
PS - Palestinian Territory 7
AE - Emirati Arabi Uniti 6
HN - Honduras 6
MY - Malesia 6
PH - Filippine 6
AL - Albania 5
BA - Bosnia-Erzegovina 5
CR - Costa Rica 5
DO - Repubblica Dominicana 5
LT - Lituania 5
PA - Panama 5
PT - Portogallo 5
SV - El Salvador 5
TW - Taiwan 5
BH - Bahrain 4
EE - Estonia 4
LV - Lettonia 4
NZ - Nuova Zelanda 4
RS - Serbia 4
AM - Armenia 3
GE - Georgia 3
HR - Croazia 3
LK - Sri Lanka 3
MD - Moldavia 3
TH - Thailandia 3
TJ - Tagikistan 3
CY - Cipro 2
DK - Danimarca 2
GD - Grenada 2
GR - Grecia 2
GY - Guiana 2
KG - Kirghizistan 2
KW - Kuwait 2
Totale 39.436
Città #
Warsaw 3.234
Fairfield 1.716
Woodbridge 1.712
Singapore 1.552
Jacksonville 1.484
Ashburn 1.419
Houston 1.020
Hong Kong 927
Ann Arbor 831
Cambridge 721
Chandler 719
Seattle 664
Wilmington 657
San Jose 641
Beijing 614
Princeton 588
Nanjing 573
The Dalles 499
Dearborn 406
New York 345
Helsinki 336
Dublin 323
Brescia 314
Los Angeles 281
Istanbul 265
Lauterbourg 263
Nanchang 206
Des Moines 163
Shenyang 162
Ho Chi Minh City 161
Munich 145
Pune 141
Tianjin 140
Buffalo 133
Milan 128
Hebei 126
Changsha 125
Jinan 121
São Paulo 116
Moscow 106
Dong Ket 100
Lancaster 99
Hanoi 95
San Francisco 93
Dallas 87
San Diego 86
Shanghai 86
Council Bluffs 80
Jiaxing 80
Santa Clara 80
Redondo Beach 79
Chicago 73
London 73
Kunming 72
Brussels 68
Orem 68
Hangzhou 53
Verona 53
Toronto 52
Phoenix 50
Turku 47
Montreal 46
Ningbo 46
Rio de Janeiro 45
Brooklyn 43
Zhengzhou 42
Frankfurt am Main 40
Guangzhou 40
Rome 38
Taizhou 38
Denver 35
Chennai 34
Johannesburg 34
Augusta 33
Jakarta 33
Manchester 33
Tokyo 33
San Mateo 31
Haikou 30
Ardabil 29
Boardman 29
Lanzhou 29
Brasília 28
Brno 28
Monmouth Junction 27
Belo Horizonte 26
Kocaeli 26
Mexico City 26
Atlanta 25
Boston 25
Norwalk 25
Tashkent 25
Leawood 24
Mumbai 23
Nairobi 23
Poplar 23
Changchun 22
Dhaka 22
Haiphong 22
Orange 20
Totale 26.852
Nome #
CHF5074 (CSP-1103) induces microglia alternative activation in plaque-free Tg2576 mice and primary glial cultures exposed to beta-amyloid 374
Neuroprotective and Anti-Apoptotic Effects of CSP-1103 in Primary Cortical Neurons Exposed to Oxygen and Glucose Deprivation 365
PEA and luteolin synergistically reduce mast cell-mediated toxicity and elicit neuroprotection in cell-based models of brain ischemia 329
Ropinirole and Pramipexole Promote Structural Plasticity in Human iPSC-Derived Dopaminergic Neurons via BDNF and mTOR Signaling 324
Targeted acetylation of NF-kappaB/RelA and histones by epigenetic drugs reduces post-ischemic brain injury in mice with an extended therapeutic window. 322
Glutamatergic neurons induce expression of functional glutamatergic synapses in primary myotubes. 319
1B/(-)IRE DMT1 Expression during Brain Ischemia Contributes to Cell Death Mediated by NF-κB/RelA Acetylation at Lys310 319
Glutamatergic Reinnervation and Assembly of Glutamatergic Synapses in Adult Rat Skeletal Muscle Occurs at Cholinergic Endplates 317
Redistribution of DAT/α-synuclein complexes visualized by “in situ” proximity ligation assay in transgenic mice modelling early Parkinson’s disease 317
Glutamatergic reinnervation through peripheral nerve graft dictates assembly of glutamatergic synapses at rat skeletal muscle 314
Priming of cultured neurons with sabeluzole results in long-lasting inhibition of neurotoxin-induced tau expression and cell death. 306
NF-κB and epigenetic mechanisms as integrative regulators of brain resilience to anoxic stress. 301
GPNMB/OA protein increases the invasiveness of human metastatic prostate cancer cell lines DU145 and PC3 through MMP-2 and MMP-9 activity 297
NF-κB in Innate Neuroprotection and Age-Related Neurodegenerative Diseases 288
Late-onset Parkinsonism in NFκB/c-Rel-deficient mice. 280
Mild inflammatory profile without gliosis in the c-rel deficient mouse modeling a late-onset parkinsonism 270
The End Is the Beginning: Parkinson's Disease in the Light of Brain Imaging 266
Nicotine-induced structural plasticity in mesencephalic dopaminergic neurons is mediated by dopamine d3 receptors and akt-mtorc1 signaling 264
The Contribution of -Synuclein Spreading to Parkinson’s Disease Synaptopathy 263
Synergistic association of valproate and resveratrol reduces brain injury in ischemic stroke 263
The "in situ" proximity ligation assay to probe protein-protein interactions in intact tissues 227
NUOVO IMPIEGO TERAPEUTICO PREVENTIVO DELLA SUBUNITA' C-REL DELLA PROTEINA NF-KAPPAB E NUOVO IMPIEGO DI UN ANIMALE TRASGENICO NON UMANO CHE PORTA LA DELEZIONE DEL GENE C-REL (C-REL-/-) 220
Mitochondria and alpha-synuclein: Friends or foes in the pathogenesis of Parkinson's disease? 210
Role of Dopamine D2/D3 Receptors in Development, Plasticity, and Neuroprotection in Human iPSC-Derived Midbrain Dopaminergic Neurons 208
Synapsin III is a key component of α-synuclein fibrils in Lewy bodies of PD brains 208
An Integrated Approach for a Structural and Functional Evaluation of Biosimilars: Implications for Erythropoietin 206
The gamma-Secretase Modulator CHF5074 Reduces the Accumulation of Native Hyperphosphorylated Tau in a Transgenic Mouse Model of Alzheimer's Disease 204
Chapter 24 NF-KappaB Dimers in the Regulation of Neuronal Survival 204
NF-kappaB p50/RelA and c-Rel-containing dimers: opposite regulators of neuron vulnerability to ischaemia. 201
Post-ischemic brain damage: NF-kappaB dimer heterogeneity as a molecular determinant of neuron vulnerability 200
Bim and Noxa are candidates to mediate the deleterious effect of the NF-kappa B subunit RelA in cerebral ischemia. 200
c-Rel deficient mice, a mouse model of "spreading" PD-like pathology. 197
The gamma-secretase modulator CHF5074 elicits neuroprotection and increases histone acetylation in primary cortical neurons exposed to oxygen glucose deprivation 196
Targeting IKK2 by pharmacological inhibitor AS602868 prevents excitotoxic injury to neurons and oligodendrocytes. 192
Alpha-synuclein aggregation and cell death triggered by energy deprivation and dopamine overload are counteracted by D2/D3 receptor activation 192
Spinal cord mGlu1a receptors - Possible target for amyotrophic lateral sclerosis therapy 190
Inhibition of Survivin Is Associated with Zoledronic Acid-induced Apoptosis of Prostate Cancer Cells 186
The proximity ligation assay: an high throughput technique for protein analysis in neuroscience 183
Expression of functional NR1/NR2B-type NMDA receptors in neuronally differentiated SK-N-SH human cell line 182
Different muscarinic receptor subtypes modulate proliferation of primary human detrusor smooth muscle cells via Akt/PI3K and map kinases. 182
A new pharmacological approach to the facilitation of acetylcholine transmission. 181
Age-related changes of enkephalin in rat spinal cord 178
Identification and characterization of a kappa B/Rel binding site in the regulatory region of the amyloid precursor protein gene. 177
α-synuclein and synapsin III cooperatively regulate synaptic function in dopamine neurons 177
Should we be cautious on the use of commercially available antibodies to dopamine receptors? 177
Depletion of Progranulin Reduces GluN2B-Containing NMDA Receptor Density, Tau Phosphorylation, and Dendritic Arborization in Mouse Primary Cortical Neurons 174
From α-synuclein to synaptic dysfunctions: new insights into the pathophysiology of Parkinson's disease 172
EXACERBATED AGE-DEPENDENT LOSS OF NIGRAL DOPAMINERGIC NEURONS IN NF-KAPPAB C-REL -/- MICE 172
c-Rel deficient mice, a mouse model of “spreading” PD-like pathology 170
Synapsin III alterations in Parkinson's disease 166
Activation of NF-kappaB p65/c-Rel dimer is associated with neuroprotection elicited by mGlu5 receptor agonists against MPP(+) toxicity in SK-N-SH cells. 166
Acute scopolamine treatment decreases dopamine metabolism in rat hippocampus and frontal cortex 165
Alpha1 adrenoceptor subtypes in human urinary bladder: sex and regional comparison. 165
Structural plasticity in mesencephalic dopaminergic neurons produced by drugs of abuse: critical role of BDNF and dopamine 165
Mitochondrial Dysfunction and Alpha-Synuclein Synaptic Pathology in Parkinson’s Disease: Who’s on First? 164
Targeting of Disordered Proteins by Small Molecules in Neurodegenerative Diseases 164
Nerve growth factor suppresses the transforming phenotype of human prolactinomas 162
Lack of coupling of D2 receptors to adenylate cyclase in GH3 cells exposed to epidermal growth factor. Possible role of a differential expression of Gi protein subtypes 162
Synergistic association of valproate and resveratrol reduces brain injury in ischemic stroke. 162
Cellular mechanisms for neurotensin receptor-mediated release of prolactin. 161
ALPHA-SYNUCLEIN MODULATES SYNAPSIN III IN NIGROSTRIATAL DOPAMINERGIC NEURONS: IMPLICATIONS FOR PARKINSON'S DISEASE 159
Computational and functional analysis of biopharmaceutical drugs in zebrafish: Erythropoietin as a test model 158
Degenerazione età –dipendente dei neuroni dopaminergici della sostanza nera nei topi NF-kappaB cRel 156
Nerve growth factor and retinoic acid interactions in the control of small cell lung cancer proliferation. 155
Acetylation of NF-kappaB p50/RelA and histones in the epigenetic regulation of pro-apoptotic transcription: a neuroprotective target in brain ischemia 155
Induction of tumour-suppressor phosphoprotein p53 in the apoptosis of cultured rat cerebellar neurones triggered by excitatory amino acids. 154
Opposing roles for D-1 and D-2 dopamine receptors in the regulation of lower esophageal sphincter motility in the rat. 154
Nerve growth factor in the anterior pituitary: localization in mammotroph cells and co-secretion with prolactin by a dopamine-regulated mechanism 154
Ketamine enhances structural plasticity in mouse mesencephalic and human iPSC-derived dopaminergic neurons via AMPAR-driven BDNF and mTOR signaling 154
Clozapine-induced alteration of glucose homeostasis in the rat: the contribution of hypothalamic-pituitary-adrenal axis activation 153
Involvement of Synapsin III in the onset of alpha-synuclein synaptic pathology in Parkinson’s disease 153
mGluR5 metabotropic glutamate receptor distribution in rat and human spinal cord: a developmental study. 152
SYNERGIC ROLE OF RESVERATROL AND HDACi MS-275 IN NEUROPROTECTION 152
Nerve growth factor directs differentiation of the bipotential cell line GH-3 into the mammotroph phenotype 148
The miR-21/PTEN/Akt signaling pathway is involved in the anti-tumoral effects of zoledronic acid in human breast cancer cell lines 148
Synapsin III is a key component of α-synuclein fibrils in Lewy bodies of Parkinson’s disease and dementia with Lewy bodies, 147
Epidermal growth factor induces the functional expression of dopamine receptors in the GH3 cell line 146
Identification of novel alternatively-spliced mRNA isoforms of metabotropic glutamate receptor 6 gene in rat and human retina. 146
Soluble interleukin-6 (IL-6) receptor/IL-6 fusion protein enhances in vitro differentiation of purified rat oligodendroglial lineage cells. 145
Inhibition of IκBα phosphorylation prevents glutamate-induced NF-κB activation and neuronal cell death 145
Tau protein immunolocalization in fetal and adult human spinal cord. 144
An in vitro method of diagnosing Parkinson's disease 144
PGRN gene silencing in primary neuronal cultures: a model of FTLD-U 144
Synapsin III Alteration in Parkinson's disease 144
Dimerization of dopamine D1 and D3 receptors in the regulation of striatal function 143
A direct interaction between dopamine D1 receptor and phosphatase Shp-2 triggers Erk activation in striatal neurons 141
Metabotropic glutamate receptor mRNA expression in rat spinal cord 141
Involvement of Synapsin III in the onset of Alpha-synuclein pathology in Parkinson’s Disease 141
Gene expression profile activated by the chemokine CCL5/RANTES in human neuronal cells 140
SNARE protein redistribution and synaptic failure in a transgenic mouse model of Parkinson's disease. 140
AAV-mediated overexpression of alpha-synuclein in midbrain dopamine neurons of Synapsin III knockout mice reveals novel molecular features involved in Parkinson's disease pathology. 140
The NMDA/D1 receptor complex as a new target in drug development 139
Differential effects of caffeine on dihydroxyphenylacetic acid concentrations in various rat brain dopaminergic structures 139
A soluble interleukin-6 (IL6) recepetor/IL6 fusion protein enhances the in vitro differentiation of purified rat oligodendroglial lineage cells 139
Opposing regulation of tau protein levels by ionotropic and metabotropic glutamate receptors in human NT2 neurons 138
Chronic lead exposure differentially affects dopamine transport in rat striatum and nucleus accumbens. 138
Chronic lead exposure alters dopaminergic mechanisms in rat pituitary 138
Acute hemodynamic and neurohumoral effects of the oral dopamine derivative ibopamine in patients with heart failure. 137
Synapsin III Alteration in Parkinson's disease 137
Different neurotransmitter systems are involved in the development of esophageal achalasia 136
Totale 19.303
Categoria #
all - tutte 180.577
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 180.577


Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2021/20222.375 169 525 34 90 26 71 138 137 116 310 208 551
2022/20232.035 333 35 68 175 180 584 0 192 294 26 70 78
2023/20241.962 127 36 159 126 108 461 72 84 400 31 40 318
2024/20254.772 29 57 36 612 530 335 492 122 650 309 981 619
2025/20268.974 862 1.213 647 1.353 871 586 1.364 344 561 722 328 123
2026/2027105 105 0 0 0 0 0 0 0 0 0 0 0
Totale 40.376