Regenerative medicine is a multidisciplinary field aimed at developing methods, molecular agents, and (nano)materials to regrow, repair, or replace damaged, malfunctioning or missing tissues. Current approaches include and combine use of stem cells, tissue engineering based on functional biodegradable scaffolds, and cell-free strategies, with stem cells and their progenitors playing the main role. However, it is now recognized that the therapeutic efficacy of stem cells largely depends on paracrine-secreted soluble factors and extracellular vesicles (EVs). Preclinical and clinical studies indicate that EVs can exert immunomodulatory and regenerative action, thus efficiently recapitulating the therapeutic effects of stem cells. On the other hand, EVs are uncapable of self-replication agents and can be nonimmunogenic, thus offering remarkable advantages and safety over stem cells for therapeutic translation. This chapter, after an introduction of EV biological and physicochemical properties, will present and discuss advances in EV-based regenerative medicine.

Extracellular vesicles in regenerative medicine

Romano, Miriam;Zendrini, Andrea;Paolini, Lucia;Busatto, Sara;Bergese, Paolo;Radeghieri, Annalisa
2020

Abstract

Regenerative medicine is a multidisciplinary field aimed at developing methods, molecular agents, and (nano)materials to regrow, repair, or replace damaged, malfunctioning or missing tissues. Current approaches include and combine use of stem cells, tissue engineering based on functional biodegradable scaffolds, and cell-free strategies, with stem cells and their progenitors playing the main role. However, it is now recognized that the therapeutic efficacy of stem cells largely depends on paracrine-secreted soluble factors and extracellular vesicles (EVs). Preclinical and clinical studies indicate that EVs can exert immunomodulatory and regenerative action, thus efficiently recapitulating the therapeutic effects of stem cells. On the other hand, EVs are uncapable of self-replication agents and can be nonimmunogenic, thus offering remarkable advantages and safety over stem cells for therapeutic translation. This chapter, after an introduction of EV biological and physicochemical properties, will present and discuss advances in EV-based regenerative medicine.
File in questo prodotto:
File Dimensione Formato  
Romano-2020-Extracellular vesicles in regenera.pdf

non disponibili

Tipologia: Full Text
Licenza: DRM non definito
Dimensione 460.68 kB
Formato Adobe PDF
460.68 kB Adobe PDF   Visualizza/Apri   Richiedi una copia

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11379/535723
 Attenzione

Attenzione! I dati visualizzati non sono stati sottoposti a validazione da parte dell'ateneo

Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus ND
  • ???jsp.display-item.citation.isi??? ND
social impact