The successful use of injection molding (IM) and micromolding (μIM) for the development of drug products is related to an in-depth knowledge of the thermal and rheological characteristics of pharmaceutical polymers and to the evaluation of their processability through experimental or modeling approaches. In this work, an investigation protocol to assess the moldability of the material through tests performed on a simple disk-shaped specimen (screening item) was developed. Ethylcellulose (EC), which is broadly employed in the formulation of prolonged delivery systems, was selected as a model pharma polymer.
Development of an investigation protocol to assess the processability of pharmaceutical polymeric materials by a micromolding press
BALDI, Francesco;
2015-01-01
Abstract
The successful use of injection molding (IM) and micromolding (μIM) for the development of drug products is related to an in-depth knowledge of the thermal and rheological characteristics of pharmaceutical polymers and to the evaluation of their processability through experimental or modeling approaches. In this work, an investigation protocol to assess the moldability of the material through tests performed on a simple disk-shaped specimen (screening item) was developed. Ethylcellulose (EC), which is broadly employed in the formulation of prolonged delivery systems, was selected as a model pharma polymer.File in questo prodotto:
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