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A method for preparing protease-polyethylene glycol adducts is presented wherein the immobilized reversible inhibitor, benzamidine, prevents reaction of activated polyethylene glycol with the active site of the protease. Improved activity against macromolecular substrates is obtained compared to when the benzamidine is in solution during the conjugation reaction.

Method to maintain the activity in polyethylene glycol-modified proteolytic enzymes

SARTORE, Luciana
1996-01-01

Abstract

A method for preparing protease-polyethylene glycol adducts is presented wherein the immobilized reversible inhibitor, benzamidine, prevents reaction of activated polyethylene glycol with the active site of the protease. Improved activity against macromolecular substrates is obtained compared to when the benzamidine is in solution during the conjugation reaction.
1996
Altra università italiana
Extraeuropeo
NO
LS7_1 Medical engineering and technology
US Patent 5,514,572
Consiglio Nazionale delle Ricerche
Inglese
Internazionale
http://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PALL&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.htm&r=1&f=G&l=50&s1=5,514,572.PN.&OS=PN/5,514,572&RS=PN/5,514,572
Brevetto concesso dallo United Stetes Patent and Trademark Office a seguito della domanda No:PCT/EP93/00205 presentata nel 1993 (PCT Pub. No.: WO93/15189; Pub No: EP0624191 in SCOPUS)
6 Brevetti::6.1 Brevetto
none
Veronese, Francesco; Caliceti, Paolo; Schiavon, Oddone; Sartore, Luciana
info:eu-repo/semantics/patent
285
4
6.1 Brevetto
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11379/159766
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